Mariza Bortolanza

TL;DR: Findings provide evidence that the development of L-DOPA-induced dyskinesia in the rat is associated with activation of glial cells that promote inflammatory responses, and indicate nitric oxide synthase inhibitors as a therapeutic strategy for preventing neuroinflammatory and glial components of dysKinesia pathogenesis in Parkinson's disease.

TL;DR: The results suggest that the antioxidant and antiinflammatory properties of fish oil supplementation are closely related to a decrease in dopaminergic damage that is caused by the 6-OHDA model of PD.

TL;DR: The repurposing of tetracyclines, a multitarget antibiotic, is proposed to treat Parkinson’s disease based on their excellent safety profiles in humans from their use for over 50 years as antibiotics.

TL;DR: It is proposed that in PD, chronically and abnormally activated microglia and astrocytes lead to an aberrant neuron‐glia communication, which affect synaptic activity and neuroplasticity contributing to the development of LID.

TL;DR: It is proposed here that the significance of inflammation in PD may go beyond the nigral cell death, and the key aims of current PD research ought to be to elucidate the time sequence in which the inflammatory factors act in PD patient brain and the mechanisms by which neuroinflammatory response contributes to the collateral effects of l‐DOPA treatment.