M
Marjan Gharagozloo
Researcher at Johns Hopkins University
Publications - 73
Citations - 2170
Marjan Gharagozloo is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Peripheral blood mononuclear cell & T cell. The author has an hindex of 24, co-authored 65 publications receiving 1458 citations. Previous affiliations of Marjan Gharagozloo include Johns Hopkins University School of Medicine & Isfahan University of Medical Sciences.
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Journal ArticleDOI
Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release
TL;DR: Astrocytes contribute to glutamate homeostasis in the CNS, by maintaining the balance between their opposing functions of glutamate uptake and release, and the main features of glutamate metabolism and glutamate excitotoxicity and its implication in CNS diseases are reviewed.
Journal ArticleDOI
A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis.
Martina Absinta,Martina Absinta,Martina Absinta,Dragan Maric,Marjan Gharagozloo,Thomas Garton,Matthew D. Smith,Jing Jin,Kathryn C. Fitzgerald,Anya Song,Poching Liu,Jing-Ping Lin,Tianxia Wu,Kory R. Johnson,Dorian B. McGavern,Dorothy P. Schafer,Peter A. Calabresi,Daniel S. Reich +17 more
TL;DR: In this article, the authors used MRI-informed single-nucleus RNA sequencing to profile the edge of demyelinated white matter lesions at various stages of inflammation and uncovered notable glial and immune cell diversity, especially at the chronically inflamed lesion edge.
Journal ArticleDOI
Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation
Pavan Bhargava,Matthew D. Smith,Leah Mische,Emily Harrington,Kathryn C. Fitzgerald,Kyle Martin,Sol Kim,Arthur Anthony Reyes,Jaime Gonzalez-Cardona,Christina Volsko,Ajai K. Tripathi,Sonal Singh,Kesava Varanasi,Hannah Noelle Lord,Keya Meyers,Michelle Taylor,Marjan Gharagozloo,Elias S. Sotirchos,Bardia Nourbakhsh,Ranjan Dutta,Ellen M. Mowry,Emmanuelle Waubant,Peter A. Calabresi +22 more
TL;DR: It is demonstrated that bile Acid metabolism is altered in MS; bile acid supplementation prevents polarization of astrocytes and microglia to neurotoxic phenotypes and ameliorates neuropathology in an animal model of MS.
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Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms.
Azam Jamshidian,Vahid Shaygannejad,Abbasali Pourazar,Sayyed-Hamid Zarkesh-Esfahani,Sayyed-Hamid Zarkesh-Esfahani,Marjan Gharagozloo,Marjan Gharagozloo +6 more
TL;DR: E evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls.
Journal ArticleDOI
Therapeutic applications of nanomedicine in autoimmune diseases: From immunosuppression to tolerance induction
TL;DR: A comprehensive review of the current status and potential of nanomedicine-based delivery strategies of immunomodulatory agents for the treatment of autoimmune disorders including psoriasis, rheumatoid arthritis, systemic lupus erythematous, scleroderma, multiple sclerosis, and type 1 diabetes.