Showing papers in "Journal of Neuroimmunology in 2013"

TL;DR: Several mechanisms of escape were identified within the tumor microenvironment: induced CD8(+)CD28(-)Foxp3(+) Tregs that may tolerize antigen presenting cells, elevated CD73 and CD39 ectonucleotidases that suppress T-cell function, and at the systemic level: elevated IL-10 levels in serum, diminished helper T- cell counts, and upregulated inhibitory CTLA-4.

TL;DR: Most patients with LGI1 exhibited abnormal brain positron emission tomography and that patients treated with steroids alone were more likely to relapse and had less favorable outcomes than those treating with steroids and intravenous immunoglobulins.

TL;DR: It is suggested that FTY720 directly promotes the neuroprotective effects of microglia and may be a potent therapeutic agent for not only multiple sclerosis but also other neurologic diseases associated with microglial activation.

TL;DR: The present meta-analysis shows that the diagnostic specificity of OCB drops from 94% to 61% if inflammatory etiologies are considered, and further illustrates the conceptional problem of substituting dissemination in space with a biomarker.

TL;DR: It is demonstrated that CS exposure in Lewis rats or those exposed to cigarette smoke and control rats can trigger multiple immune and oxidative responses that may have important roles in the pathogenesis of CNS inflammatory neurological diseases.

TL;DR: It is suggested that AD pathogenesis may be influenced by systemic immunologic dysfunction and provides potential immunologic targets for therapeutic intervention.

TL;DR: The results suggest that neuroinflammatory markers might be involved in memory impairment via modulating the NMDA receptor in STZ induced memory impaired rats.

TL;DR: Evidence is provided that GM-CSF modulation of immunity could be of clinical benefit for Parkinson's disease and novel immune-based neuronal protection pathways linked to the upregulation of IL-27 are revealed.

TL;DR: The data suggest the presence of overactivation and expansion of circulating counterparts of TFH cells in MG patients, which may contribute to the immunopathogenesis of MG.

TL;DR: This review examines the link between MCs and nociceptive process, at the periphery as well as in the CNS, and proposes that paracrine-like action of MCs on synaptic transmission might also signal a modulation of the nervous system by the immune system.

TL;DR: PTX3 expression differed across low and high-grade tumors based on histopathological diagnosis and clinical severity, positively correlating with tumor grade and severity in a multivariate logistic regression model.

TL;DR: It is demonstrated that FACS-sorted malignant glioma-derived pericytes (HMGP) were characterized by the expression of CD90, CD248, and platelet-derived growth factor receptor-β (PDGFR-β), and suggested that these cells, besides their critical role in tumor vascularization, also promote local immunosuppression in malignantgliomas and possibly other brain diseases.

TL;DR: The interactions between a prior program of regular exercise and the development of experimental autoimmune encephalomyelitis (EAE)-mediated responses were evaluated and cytokine and derived neurotrophic factor levels were altered, and the clinical score was attenuated.

TL;DR: Investigation of teriflunomide's effects on proliferation, activation, survival, and function of stimulated human peripheral blood mononuclear cell subsets in vitro found it acts on multiple immune cell types and processes via DHODH-dependent and independent mechanisms.

TL;DR: E evaluation of Treg and Th17 frequency in peripheral blood of a group of relapsed MS patients, showed a decrease in Treg/Th17 ratio compared to that of healthy controls.

TL;DR: The results of the study indicated that Prx I is an antioxidant that is up-regulated in a ROS/p38 MAPK-dependent manner and governs the progression of neuroinflammation by suppressing microglial activation.

TL;DR: CSF of healthy volunteers was examined by flow cytometry for T-lymphocyte surface markers 5 weeks after administration of intravenous vedolizumab 450 mg and no significant changes were observed in CSF T-LYmphocyte populations.

TL;DR: The findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.

TL;DR: The notion that genetic variation in NLRP3 gene may contribute to LOAD risk in Northern Han Chinese is supported, and the minor A allele of rs35829419 (Q705K) polymorphism appeared to exert a protective effect against the development of LOAD.

TL;DR: Assessment of the diagnostic accuracy of a nephelometric assay for k free light chain determination in cerebrospinal fluid and serum indicates that kFLC Index seems to be more accurate than other parameters.

TL;DR: The study revealed mitochondrial complex IV and superoxide dismutase activity alterations in both the pathology-affected CC and the non-affected SC, raising the possibility that regionally different subcellular molecular interactions lead to the selective oligodendrocyte loss induced by the nonselective mitochondrial toxin, cuprizone.

TL;DR: The results demonstrate that supplementation with melatonin SPMS patients should be taken into account, especially in progressive form of MS.

TL;DR: In patients with a Clinically Isolated Syndrome, a lower age at onset, an onset with optic neuritis and the presence of CSF-restricted IgMOB increased the risk of a relapse, whereas in those who had performed a baseline spinal tap and MRI scan, the absence of this condition predicted a relapse within one year.

TL;DR: In the EPA-treated mice, IFN-γ and IL-17 productions were remarkably inhibited and the expression levels of peroxisome proliferator-activated receptors were significantly enhanced in the CNS-infiltrating CD4T cells, suggesting EPA shows promise as a potential new therapeutic agent against multiple sclerosis.

TL;DR: A single streptozotocin injection in mice can induce significant neuropathic pain along with an increase in plasma glucose levels and a decrease in body weight, and an upregulation of C1q-positive cells was observed seven days after the administration of STZ.

TL;DR: The study offers new insight into the cellular inflammatory response that occurs after SCI and suggests that the timing and targets of anti-inflammatory therapies may be crucial to maximize neuroprotection at the acute and more chronic stages of SCI.

TL;DR: This case highlights cerebellar ataxia in the absence of seizures as a clinical manifestation of GABAB receptor autoimmunity and extends the spectrum of tumors underlying this condition to malignant melanoma.

TL;DR: In conclusion, allergy may be a contributing factor to the increased serum levels of anti-MBP and anti-MAG auto-antibodies in some autistic children.

TL;DR: Data suggest that central β-AR stimulation is sufficient to prime microglia cytokine responses, and indicates that centralβ-AR antagonism prevents priming ofmicroglia in mice exposed to chronic stress.

TL;DR: Gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients are demonstrated, suggesting that NETs may underlie gender-specific differences in MS pathogenesis.