M
Mark A. Valasek
Researcher at University of California, San Diego
Publications - 111
Citations - 8083
Mark A. Valasek is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Nonalcoholic fatty liver disease & Fatty liver. The author has an hindex of 36, co-authored 98 publications receiving 6141 citations. Previous affiliations of Mark A. Valasek include University of Texas Southwestern Medical Center & University of Washington Medical Center.
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Journal ArticleDOI
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
Yumei Xiong,Norimasa Miyamoto,Kenji Shibata,Mark A. Valasek,Toshiyuki Motoike,Rafal M. Kedzierski,Masashi Yanagisawa +6 more
TL;DR: C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture, suggesting the relevance of this pathway in vivo.
Journal ArticleDOI
The power of real-time PCR.
Mark A. Valasek,Joyce J. Repa +1 more
TL;DR: The basic concepts, chemistries, and instrumentation of real-time PCR are discussed and the present applications and future perspectives for this technology in biomedical sciences and in life science education are included.
Journal ArticleDOI
Review article: the global emergence of Helicobacter pylori antibiotic resistance.
Irene Thung,H. Aramin,Vera Vavinskaya,Samir Gupta,Jason Y. Park,Sheila E. Crowe,Mark A. Valasek +6 more
TL;DR: This study highlights the importance of knowing the carrier and removal status of canine coronavirus, as a source of infection for other animals, not necessarily belonging to the same breeds.
Journal ArticleDOI
Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients with Biopsy-proven Nonalcoholic Fatty Liver Disease
Charlie C. Park,Phirum Nguyen,Carolyn Hernandez,Ricki Bettencourt,Kimberly Ramirez,Lynda Fortney,Jonathan Hooker,Ethan Z. Sy,Michael T. Savides,Mosab H. Alquiraish,Mark A. Valasek,Emily Rizo,Lisa Richards,David A. Brenner,Claude B. Sirlin,Rohit Loomba +15 more
TL;DR: In a prospective, cross-sectional study of more than 100 patients, MRE is found to be more accurate than TE in identification of liver fibrosis (stage 1 or more), using biopsy analysis as the standard and MRI-PDFF is more accurate in detecting all grades of steatosis in patients with NAFLD.
Journal ArticleDOI
ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development
Hayato Nakagawa,Atsushi Umemura,Koji Taniguchi,Joan Font-Burgada,Debanjan Dhar,Hisanobu Ogata,Zhenyu Zhong,Mark A. Valasek,Ekihiro Seki,Juan Hidalgo,Kazuhiko Koike,Randal J. Kaufman,Michael Karin +12 more
TL;DR: Both NASH and HCC development were dependent on TNF produced by inflammatory macrophages that accumulate in the MUP-uPA liver in response to hepatocyte ER stress.