O
Oxana K. Pickeral
Researcher at National Institutes of Health
Publications - 18
Citations - 4801
Oxana K. Pickeral is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome & Gene. The author has an hindex of 14, co-authored 18 publications receiving 4629 citations. Previous affiliations of Oxana K. Pickeral include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Comparative Genomics of the Eukaryotes
Gerald M. Rubin,Mark Yandell,Jennifer R. Wortman,George L. Gabor,Miklos,Catherine R. Nelson,Iswar K. Hariharan,Mark E. Fortini,Peter W. Li,Rolf Apweiler,Wolfgang Fleischmann,J. Michael Cherry,Steven Henikoff,Marian P. Skupski,Sima Misra,Michael Ashburner,Ewan Birney,Mark S. Boguski,Thomas Brody,Peter Brokstein,Susan E. Celniker,Stephen A. Chervitz,David Coates,Anibal Cravchik,Andrei Gabrielian,Richard F. Galle,William M. Gelbart,Reed A. George,Lawrence S.B. Goldstein,Fangcheng Gong,Ping Guan,Nomi L. Harris,Bruce A. Hay,Roger A. Hoskins,Jiayin Li,Zhenya Li,Richard O. Hynes,Steven J.M. Jones,Peter M. Kuehl,Bruno Lemaitre,J. Troy Littleton,Deborah K. Morrison,Christopher J. Mungall,Patrick H. O'Farrell,Oxana K. Pickeral,Chris Shue,Leslie B. Vosshall,Jiong Zhang,Qi Zhao,Xiangqun H. Zheng,Fei Zhong,Wenyan Zhong,Richard A. Gibbs,J. Craig Venter,Mark Raymond Adams,Suzanna E. Lewis +55 more
TL;DR: The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
Journal ArticleDOI
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia.
Andreas Rosenwald,Ash A. Alizadeh,George F. Widhopf,Richard M. Simon,R. Eric Davis,Xin Yu,Liming Yang,Oxana K. Pickeral,Laura Z. Rassenti,John Powell,David Botstein,John C. Byrd,Michael R. Grever,Bruce D. Cheson,Nicholas Chiorazzi,Wyndham H. Wilson,Thomas J. Kipps,Patrick O. Brown,Louis M. Staudt +18 more
TL;DR: Using genomic-scale gene expression profiling, CLL is characterized by a common gene expression “signature,” irrespective of Ig mutational status, suggesting that CLL cases share a common mechanism of transformation and/or cell of origin.
Journal ArticleDOI
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol.
Lloyd T. Lam,Oxana K. Pickeral,Amy C Peng,Andreas Rosenwald,Elaine M. Hurt,Jena M. Giltnane,Lauren Averett,Hong Zhao,R. Eric Davis,Mohan Sathyamoorthy,Larry M. Wahl,Eric D Harris,Judy A Mikovits,Anne Monks,Melinda G. Hollingshead,Edward A. Sausville,Louis M. Staudt +16 more
TL;DR: The present genomic-scale measurement of mRNA turnover uncovered a regulatory logic that links gene function with mRNA half-life, and suggests that flavopiridol may be more effective against types of cancer that are highly dependent on genes with unstable mRNAs.
Journal ArticleDOI
Signatures of the Immune Response
Arthur L. Shaffer,Andreas Rosenwald,Elaine M. Hurt,Jena M. Giltnane,Lloyd T. Lam,Oxana K. Pickeral,Louis M. Staudt +6 more
TL;DR: The transcriptional repression signature of BCL-6 reveals how this factor can prevent terminal differentiation of B cells and cause B cell lymphomas.
Journal ArticleDOI
Frequent Human Genomic DNA Transduction Driven by LINE-1 Retrotransposition
TL;DR: Using bioinformatic approaches to analyze the structures of L1 element target site duplications and flanking sequence features, evidence is provided suggesting that approximately 15% of full-length L1 elements bear evidence of flanking DNA segment transduction.