M
Mark G. Poolman
Researcher at Oxford Brookes University
Publications - 48
Citations - 2595
Mark G. Poolman is an academic researcher from Oxford Brookes University. The author has contributed to research in topics: Metabolic network & Light intensity. The author has an hindex of 25, co-authored 44 publications receiving 2211 citations. Previous affiliations of Mark G. Poolman include Montana State University & University of Oxford.
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Journal ArticleDOI
Modular decomposition of metabolic systems via null-space analysis.
TL;DR: A new concept--the reaction correlation coefficient, phi, is introduced and it is shown that this is a logical extension of the concept of enzyme (or reaction) subsets, and that reaction correlation coefficients are uniquely defined, even though the basis of the null-space is not.
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Identification of potential drug targets in Salmonella enterica sv. Typhimurium using metabolic modelling and experimental validation
Hassan B. Hartman,David A. Fell,Sergio Rossell,Peter Ruhdal Jensen,Martin J. Woodward,Lotte Thorndahl,Lotte Jelsbak,John Elmerdahl Olsen,Anu Raghunathan,Simon Daefler,Mark G. Poolman +10 more
TL;DR: Based on the genome sequence of S. Typhimurium and associated databases, a genome-scale metabolic model was constructed and Eleven sets of one and two reactions were found to be essential for the production of biomass precursors.
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The intertwined metabolism during symbiotic nitrogen fixation elucidated by metabolic modelling.
Thomas Pfau,Nils Christian,Shyam K. Masakapalli,Lee J. Sweetlove,Mark G. Poolman,Oliver Ebenhöh +5 more
TL;DR: A fully compartmentalised, mass and charge-balanced, genome-scale model of the clover Medicago truncatula, which has been adopted as a model organism for legumes, is described, providing a modelling framework, in which the interlinked metabolism of plants and nodules can be studied from a theoretical perspective.
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Identification of Metabolic Pathways Essential for Fitness of Salmonella Typhimurium In Vivo
Lotte Jelsbak,Hassan B. Hartman,Casper Schroll,Jesper T. Rosenkrantz,Sebastien Lemire,Inke Wallrodt,Line Elnif Thomsen,Mark G. Poolman,Mogens Kilstrup,Peter Ruhdal Jensen,John Elmerdahl Olsen +10 more
TL;DR: A computer model of the metabolic network of Salmonella enterica serovar Typhimurium was used and pairs of reactions predicted to be required for growth in vivo were identified, adding to the existing knowledge of available nutrients in the intra-host environment, and identifying possible new targets for antibiotics.
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Model-based biotechnological potential analysis of Kluyveromyces marxianus central metabolism
Agris Pentjuss,Egils Stalidzans,Janis Liepins,Agnese Kokina,Jekaterina Martynova,Peteris Zikmanis,I Mozga,Rita Scherbaka,Hassan B. Hartman,Mark G. Poolman,David A. Fell,Armands Vigants +11 more
TL;DR: The application of a biomass-linked stoichiometric model of central metabolism that is experimentally validated, and mass and charge balanced for assessing the carbon conversion efficiency of wild type and modified K. marxianus is shown.