M
Mark G. Sterken
Researcher at Wageningen University and Research Centre
Publications - 84
Citations - 2012
Mark G. Sterken is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Population & Gene. The author has an hindex of 19, co-authored 72 publications receiving 1507 citations. Previous affiliations of Mark G. Sterken include Russian Academy of Sciences & University of Paris-Sud.
Papers
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Journal ArticleDOI
Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans
L. Basten Snoek,Mark G. Sterken,Roel P. J. Bevers,Rita J. M. Volkers,Arjen E. van’t Hof,Rachel Brenchley,Joost A. G. Riksen,Andrew R. Cossins,Jan E. Kammenga +8 more
TL;DR: These results illustrate the highly dynamic pattern of CGV across three different environmental conditions that can be evoked by a stress response over a relatively short time-span (2 h) and that CGV is mainly determined by response related trans regulatory eQTL.
Journal ArticleDOI
Noncoding Flavivirus RNA Displays RNA Interference Suppressor Activity in Insect and Mammalian Cells
Esther Schnettler,Mark G. Sterken,Jason Y. Leung,Stefan W. Metz,Corrine Geertsema,Rob Goldbach,Just M. Vlak,Alaine Kohl,Alaine Kohl,Alexander A. Khromykh,Gorben P. Pijlman +10 more
TL;DR: The results of the present study suggest a novel role for sfRNA, i.e., as a nucleic acid-based regulator of RNAi pathways, a strategy that may be conserved among flaviviruses.
Journal ArticleDOI
The laboratory domestication of Caenorhabditis elegans.
TL;DR: Could selective pressures that led to the fixation of laboratory-derived alleles for the genes npr-1, glb-5, and nath-10 influence a large number of traits, resulting in behaviors that affect experimental interpretations.
Journal ArticleDOI
Remarkably divergent regions punctuate the genome assembly of the Caenorhabditis elegans Hawaiian strain CB4856
Owen Thompson,L. Basten Snoek,Harm Nijveen,Mark G. Sterken,Rita J. M. Volkers,Rachel Brenchley,Arjen van 't Hof,Roel P. J. Bevers,Andrew R. Cossins,Itai Yanai,Alex Hajnal,Tobias Schmid,Jaryn D. Perkins,David H. Spencer,Leonid Kruglyak,Erik C. Andersen,Donald G. Moerman,LaDeana W. Hillier,Jan E. Kammenga,Robert H. Waterston +19 more
TL;DR: The draft sequence makes available a comprehensive catalog of sequence differences between the CB4856 and N2 strains that will facilitate the molecular dissection of their phenotypic differences, and emphasizes the importance of going beyond simple alignment of reads to a reference genome when assessing differences between genomes.
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Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses
Esther Schnettler,Hana Tykalová,Mick Watson,Mayuri Sharma,Mark G. Sterken,Darren J. Obbard,Samuel H. Lewis,Melanie McFarlane,Lesley Bell-Sakyi,Gerald Barry,Sabine Weisheit,Sonja M. Best,Richard J. Kuhn,Gorben P. Pijlman,Margo Chase-Topping,Ernest A. Gould,Libor Grubhoffer,John K. Fazakerley,Alain Kohl,Alain Kohl +19 more
TL;DR: The results characterize the antiviral RNAi response in tick cells including phylogenetic analysis of genes encoding antiviral proteins, and viral interference with this pathway, and shows important differences in antiviralRNAi between the two major classes of arbovirus vectors.