M
Mark H. Soonpaa
Researcher at Indiana University – Purdue University Indianapolis
Publications - 4
Citations - 2424
Mark H. Soonpaa is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Cellular differentiation & Myocyte. The author has an hindex of 3, co-authored 4 publications receiving 2390 citations. Previous affiliations of Mark H. Soonpaa include University of Wisconsin-Madison.
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Journal ArticleDOI
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry,Mark H. Soonpaa,Hans Reinecke,Hidehiro Nakajima,Hisako O. Nakajima,Michael Rubart,Kishore B.S. Pasumarthi,Kishore B.S. Pasumarthi,Jitka A. I. Virag,Stephen H. Bartelmez,Veronica Poppa,Gillian Bradford,Joshua D. Dowell,David A. Williams,David A. Williams,Loren J. Field +15 more
TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.
Journal ArticleDOI
Parthenogenetic stem cells for tissue-engineered heart repair
Michael Didié,Peter Christalla,Michael Rubart,Vijayakumar Muppala,Stephan Döker,Bernhard Unsöld,Ali El-Armouche,Thomas Rau,Thomas Eschenhagen,Alexander P. Schwoerer,Heimo Ehmke,Udo Schumacher,Sigrid Fuchs,Claudia Lange,Alexander Becker,Alexander Becker,Wen Tao,John A. Scherschel,Mark H. Soonpaa,Tao Yang,Qiong Lin,Martin Zenke,Dong Wook Han,Dong Wook Han,Hans R. Schöler,Cornelia Rudolph,Doris Steinemann,Brigitte Schlegelberger,Steven J. Kattman,Alec D. Witty,Gordon Keller,Loren J. Field,Wolfram-Hubertus Zimmermann +32 more
TL;DR: The data demonstrate pluripotency, with unrestricted cardiogenicity in PSCs, and introduce this unique cell type as an attractive source for tissue-engineered heart repair.
Journal ArticleDOI
Length dependence of Ca2+ sensitivity of tension in mouse cardiac myocytes expressing skeletal troponin C.
Kerry S. McDonald,Loren J. Field,M. S. Parmacek,Mark H. Soonpaa,J. M. Leiden,Richard L. Moss +5 more
TL;DR: It is concluded that the Ca2+ sensitivity of tension in myocytes changes as a function of sarcomere length but is independent of the isoform of troponin C present in the thin filaments.
Book ChapterDOI
Potential Approaches For Cell-Mediated Myocardial Repair
TL;DR: Several approaches designed to provide either temporary or long-term augmentation of myocardial function have been proposed and/or attempted, including the use of ventricular assist devices, development of mechanical hearts, cardiomyoplasty, and xenograft transplant.