M
Mark T. Albrecht
Researcher at Naval Medical Research Center
Publications - 8
Citations - 215
Mark T. Albrecht is an academic researcher from Naval Medical Research Center. The author has contributed to research in topics: Bacillus anthracis & DNA vaccination. The author has an hindex of 5, co-authored 8 publications receiving 208 citations.
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Journal ArticleDOI
Human Monoclonal Antibodies against Anthrax Lethal Factor and Protective Antigen Act Independently To Protect against Bacillus anthracis Infection and Enhance Endogenous Immunity to Anthrax
Mark T. Albrecht,Han Li,E. Diane Williamson,Chris S. LeButt,Helen C. Flick-Smith,Conrad P. Quinn,Hans Westra,Darrell R. Galloway,Alfred J. Mateczun,Stanley Goldman,Herman Groen,Les Baillie +11 more
TL;DR: Based on results, IQNPA and IQNLF act independently during prophylactic anthrax treatment and do not interfere with the establishment of endogenous immunity.
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Ultra-fast pg/ml anthrax toxin (protective antigen) detection assay based on microwave-accelerated metal-enhanced fluorescence
TL;DR: It is shown that the fluorescent probe, covalently attached to the secondary antibody, plays a crucial role of indicating complex formation in a metal-enhanced fluorescence (MEF)-PA assay using a combination of the MEF effect and microwave-accelerated PA protein surface absorption.
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A non-glycosylated, plant-produced human monoclonal antibody against anthrax protective antigen protects mice and non-human primates from B. anthracis spore challenge
Vadim Mett,Jessica A. Chichester,Michelle Stewart,Konstantin Musiychuk,Hong Bi,Carolyn J. Reifsnyder,Anna Hull,Mark T. Albrecht,Stanley Goldman,Les Baillie,Vidadi Yusibov +10 more
TL;DR: The potential of a plant-produced non-glycosylated antibody as a useful tool for the treatment of inhalation anthrax is demonstrated and is demonstrated to be superior to pp-mAbPA.
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Electroporation of a multivalent DNA vaccine cocktail elicits a protective immune response against anthrax and plague
Mark T. Albrecht,Brian D. Livingston,John T. Pesce,Matthew G. Bell,Drew Hannaman,Andrea M. Keane-Myers +5 more
TL;DR: The feasibility of electroporation to deliver and maintain the overall efficacy of an anthrax-plague DNA vaccine cocktail whose individual components have qualitative immunological differences when combined is demonstrated.
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Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model
TL;DR: A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolization Y.pestis.