H
Hans Westra
Publications - 10
Citations - 373
Hans Westra is an academic researcher. The author has contributed to research in topics: Staphylococcus aureus & Bacillus anthracis. The author has an hindex of 7, co-authored 10 publications receiving 357 citations.
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Journal ArticleDOI
Human Monoclonal Antibodies against Anthrax Lethal Factor and Protective Antigen Act Independently To Protect against Bacillus anthracis Infection and Enhance Endogenous Immunity to Anthrax
Mark T. Albrecht,Han Li,E. Diane Williamson,Chris S. LeButt,Helen C. Flick-Smith,Conrad P. Quinn,Hans Westra,Darrell R. Galloway,Alfred J. Mateczun,Stanley Goldman,Herman Groen,Les Baillie +11 more
TL;DR: Based on results, IQNPA and IQNLF act independently during prophylactic anthrax treatment and do not interfere with the establishment of endogenous immunity.
Journal ArticleDOI
Human-derived, plant-produced monoclonal antibody for the treatment of anthrax
Anna Hull,Carolyn J. Criscuolo,Vadim Mett,Herman Groen,Wilma Steeman,Hans Westra,Gail Chapman,Bart Legutki,Les Baillie,Les Baillie,Vidadi Yusibov +10 more
TL;DR: The feasibility of producing a protective, human-derived, monoclonal antibody directed against the protective antigen of Bacillus anthracis in plants is reported, able to neutralize toxin activity in vitro and in vivo at a comparable level to that seen for its hybridoma-produced counterpart.
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A human monoclonal antibody targeting the conserved staphylococcal antigen IsaA protects mice against Staphylococcus aureus bacteremia
Sanne van den Berg,Hendrik P. J. Bonarius,Kok P. M. van Kessel,Goffe S. Elsinga,Neeltje Kooi,Hans Westra,Tjibbe Bosma,Magdalena M. van der Kooi-Pol,Danny G. A. M. Koedijk,Herman Groen,Jan Maarten van Dijl,Girbe Buist,Irma A. J. M. Bakker-Woudenberg +12 more
TL;DR: The development of the human anti-IsaA IgG1 mAb 1D9, which was shown to bind to all 26 S. aureus isolates tested, is reported, which shows that healthy S.aureus carriers elicit an immune response which is sufficient to generate protective mAbs against invariant staphylococcal surface antigens.
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High anti-staphylococcal antibody titers in patients with epidermolysis bullosa relate to long-term colonization with alternating types of staphylococcus aureus
Magdalena M. van der Kooi-Pol,Corné P. de Vogel,Gerlinde N. Westerhout-Pluister,Yanka K. Veenstra-Kyuchukova,José C. Duipmans,Corinna Glasner,Girbe Buist,Goffe S. Elsinga,Hans Westra,Hendrik P. J. Bonarius,Herman Groen,Willem J. B. van Wamel,Hajo Grundmann,Marcel F. Jonkman,Jan Maarten van Dijl +14 more
TL;DR: Abbreviations: EB, epidermolysis bullosa; ET, exfoliative toxin; HlgB, gamma-hemolysin B; IsaA, immunodominant antigen A; Isd, iron-responsive surface determinant; Luk, leukocidin; LytM, peptidoglycan hydrolase; MFI, median fluorescence intensity; MLVA, multiple-locus variable number of tandem repeats analysis.
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Surface shaving as a versatile tool to profile global interactions between human serum proteins and the Staphylococcus aureus cell surface
Annette Dreisbach,Magdalena M. van der Kooi-Pol,Andreas Otto,Katrin Gronau,Hendrik P. J. Bonarius,Hans Westra,Herman Groen,Doerte Becher,Michael Hecker,Jan Maarten van Dijl +9 more
TL;DR: It is concluded that surface shaving is a versatile tool to profile global interactions between human serum proteins and the S. aureus cell surface and several components of the complement system, the platelet factor 4 and the isoform 1 of the inter‐α‐trypsin inhibitor heavy chain H4 on the staphylococcal cell surface are identified.