M
Marko Mrkobrada
Researcher at University of Western Ontario
Publications - 55
Citations - 5491
Marko Mrkobrada is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Perioperative & Randomized controlled trial. The author has an hindex of 24, co-authored 47 publications receiving 4306 citations. Previous affiliations of Marko Mrkobrada include London Health Sciences Centre & University of Manitoba.
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Journal ArticleDOI
Association between postoperative troponin levels and 30-day mortality among patients undergoing noncardiac surgery
Philip J. Devereaux,Matthew T. V. Chan,Pablo Alonso-Coello,Michael Walsh,Otavio Berwanger,Juan Carlos Villar,Chew Yin Wang,R. I. Garutti,Michael J. Jacka,Alben Sigamani,Sadeesh Srinathan,Bruce M Biccard,Clara K Chow,Valsamma Abraham,Maria Tiboni,Susan M. Pettit,Wojciech Szczeklik,G. Lurati Buse,Fernando Botto,Gordon H. Guyatt,Diane Heels-Ansdell,Daniel I. Sessler,Kristian Thorlund,Amit X. Garg,Marko Mrkobrada,Sabu Thomas,Reitze N. Rodseth,Rupert M Pearse,Lehana Thabane,Matthew J. McQueen,Tomas VanHelder,Mohit Bhandari,Jackie Bosch,Andrea Kurz,Carisi Anne Polanczyk,Germán Málaga,Peter Nagele,Y Le Manach,Martin Leuwer,Salim Yusuf +39 more
TL;DR: Among patients undergoing noncardiac surgery, the peak postoperative troponin T measurement during the first 3 days after surgery was significantly associated with 30-day mortality.
Journal ArticleDOI
Myocardial Injury after Noncardiac Surgery: A Large, International, Prospective Cohort Study Establishing Diagnostic Criteria, Characteristics, Predictors, and 30-day Outcomes
Fernando Botto,Pablo Alonso-Coello,Matthew T. V. Chan,Matthew T. V. Chan,Juan Carlos Villar,Denis Xavier,Sadeesh Srinathan,Gordon H. Guyatt,Patricia Cruz,Patricia Cruz,Michelle M. Graham,Michelle M. Graham,Chew Yin Wang,Otavio Berwanger,R.M. Pearse,R.M. Pearse,Bruce M Biccard,Valsa Abraham,Germán Málaga,Germán Málaga,Graham S. Hillis,Graham S. Hillis,Reitze N. Rodseth,Deborah J. Cook,Deborah J. Cook,Deborah J. Cook,Carisi Anne Polanczyk,Wojciech Szczeklik,Daniel I. Sessler,Daniel I. Sessler,Tej Sheth,Tej Sheth,Gareth L Ackland,Gareth L Ackland,Martin Leuwer,Amit X Garg,Amit X Garg,Yannick LeManach,Yannick LeManach,Shirley Pettit,Diane Heels-Ansdell,Giovanna Luratibuse,Giovanna Luratibuse,Michael Walsh,Michael Walsh,Robert Sapsford,Holger J Schünemann,Holger J Schünemann,Andrea Kurz,Andrea Kurz,Sabu Thomas,Marko Mrkobrada,Marko Mrkobrada,Lehana Thabane,Hertzel C. Gerstein,Pilar Paniagua,Pilar Paniagua,Peter Nagele,Peter Nagele,Parminder Raina,Salim Yusuf,Salim Yusuf,Salim Yusuf,Philip J. Devereaux,Philip J. Devereaux,Matthew J. McQueen,Mohit Bhandari,Jackie Bosch,Norman Buckley,Clara K Chow,Richard Halliwell,Stephen Li,Vincent W. Lee,J. Mooney,Mariana Vargas Furtado,Erica Aranha Suzumura,Eliana Vieira Santucci,Katia R. M. Leite,Jose Amalth do Espirirto Santo,César A. Jardim,Alexandre Biasi Cavalcanti,Hélio Penna Guimarães,Michael J Jacka,Finlay A. McAlister,Sean McMurtry,Derek R. Townsend,Neesh Pannu,Sean M. Bagshaw,Amal Bessissow,Emmanuelle Duceppe,John W. Eikelboom,Javier Ganame,James Hankinson,Stephen Hill,Sanjit S. Jolly,Andre Lamy,Elizabeth Ling,Patrick Magloire,Guillaume Paré,Deven Reddy,David Szalay,Jacques G. Tittley,Jeff Weitz,Richard P. Whitlock,Saeed Darvish-Kazim,Justin DeBeer,Peter A. Kavsak,Clive Kearon,Richard Mizera,Martin O'Donnell,Matthew B. McQueen,Jehonathan H. Pinthus,Sebastian Ribas,Marko Simunovic,Vikas Tandon,Tomas VanHelder,Mitchell Winemaker,Sarah D. McDonald,Paul M. O'Bryne,Ameen Patel,James Paul,Zubin Punthakee,Karen Raymer,Omid Salehian,Frederick A. Spencer,Stephen D. Walter,Andrew Worster,Anthony Adili,Catherine M. Clase,Mark Crowther,James D. Douketis,Azim S. Gangji,Paul Jackson,Wendy Lim,Peter Lovrics,Sergio Mazzadi,William Orovan,Jill Rudkowski,Mark Soth,Maria Tiboni,Rey R. Acedillo,Amit Garg,Amit Garg,Ainslie Hildebrand,Ngan N. Lam,Danielle MacNeil,Pavel S Roshanov,Sadeesh K Srinathan,Clare D. Ramsey,Philip St John,Laurel Thorlacius,Faisal Siddiqui,Hilary P Grocott,Andrew McKay,Trevor W R Lee,Ryan J. J. Amadeo,Duane J. Funk,Heather McDonald,James Zacharias,Olga L. Cortés,Maria Stella Chaparro,Skarlett Vásquez,Alvaro Castañeda,Silvia Moreira Ayub Ferreira,Pierre Coriat,Denis Monneret,Jean Pierre Goarin,Cristina Ibanez Esteve,Catherine Royer,Georges Daas,Gordon Y.S. Choi,Tony Gin,Lydia C.W. Lit,Alben Sigamani,Atiya Faruqui,Radhika Dhanpal,Smitha Almeida,Joseph Cherian,Sultana Furruqh,Lalita Afzal,P. George,Shaveta Mala,Holger Schünemann,Holger Schünemann,Paola Muti,Enrico Vizza,Gracie Ong,Marzida Mansor,Alvin S.B. Tan,Ina Ismiarti Shariffuddin,V Vasanthan,Noorjahan Haneem Md Hashim,A. Wahab Undok,Ushananthini Ki,Hou Yee Lai,Wan Azman Ahmad,Azad Hassan Abdul Razack,Vanessa Valderrama-Victoria,Javier D Loza-Herrera,Maria De Los Angeles Lazo,Aida Rotta-Rotta,Barbara Sokołowska,Jacek Musial,Jacek Górka,Paweł Iwaszczuk,Mateusz Kózka,Maciej Chwała,Marcin Raczek,Tomasz Mrowiecki,Bogusz Kaczmarek,B M Biccard,Hussein Cassimjee,Dean Gopalan,Theroshnie Kisten,Aine Mugabi,P. Naidoo,Rubeshan Naidoo,R.N. Rodseth,D.L. Skinner,Alex Torborg,Gerard Urrútia,Mari Luz Maestre,Miquel Santaló,Raúl Gonzalez,Adrià Font,Cecilia Martínez,Xavier Pelaez,Marta De Antonio,José Villamor,Jesús Alvarez García,Maria José Ferré,Ekaterina Popova,Ignacio Garutti,Carmen Fernández,Maria Palencia,Susana Díaz,Teresa Del Castillo,Alberto Varela,Angeles de Miguel,Manuel Muñoz,Patricia Piñeiro,Gabriel Cusati,Maria Del Barrio,Maria José Membrillo,David Orozco,Fidel Reyes,Robert J. Sapsford,Julian H. Barth,Julian Scott,Alistair Hall,Simon J. Howell,Michaela Lobley,Janet Woods,Susannah Howard,Joanne Fletcher,Nikki Dewhirst,C. Williams,A. Rushton,Ingeborg Welters,M Leuwer,Rupert Pearse,Rupert Pearse,G.L. Ackland,G.L. Ackland,Ahsun Khan,Edyta Niebrzegowska,Sally Benton,Andrew Wragg,Andrew Archbold,Amanda Smith,Eleanor McAlees,Cheryl Ramballi,Neil MacDonald,Marta Januszewska,Robert C M Stephens,Anna Reyes,Laura Gallego Paredes,Pervez Sultan,David Cain,John Whittle,Ana Gutierrez del Arroyo,Zhuo Sun,Patrick S Finnegan,Cameron Egan,Hooman Honar,Aram Shahinyan,Krit Panjasawatwong,Alexander Y. Fu,Sihe Wang,Edmunds Reineks,Jane Blood,Megan Kalin,David W. Gibson,Troy S. Wildes,Vascular Events In Noncardiac Surgery Patients Cohort Evaluation (Vision) Investigators +294 more
TL;DR: Among adults undergoing noncardiac surgery, MINS was an independent predictor of 30-day mortality and had the highest population-attributable risk of the perioperative complications.
Journal ArticleDOI
Aspirin in Patients Undergoing Noncardiac Surgery
Marko Mrkobrada,Marko Mrkobrada,Kate Leslie,Pablo Alonso-Coello,Andrea Kurz,Alben Sigamani,Gordon H. Guyatt,A. Robinson,F. Botto,G. Lurati Buse,G. Lurati Buse,Denis Xavier,Maria Tiboni,Deborah J. Cook,Patrice Forget,Germán Málaga,Edith Fleischmann,Mohammed Amir,John W. Eikelboom,John W. Eikelboom,Ryszard Mizera,David Torres,Tomas VanHelder,Pilar Paniagua,Otavio Berwanger,Sadeesh Srinathan,Michelle M. Graham,Laura Pasin,Y Le Manach,Y Le Manach,Peggy Gao,Janice Pogue,Janice Pogue,Richard P. Whitlock,Richard P. Whitlock,Andre Lamy,Andre Lamy,Clive Kearon,Colin Baigent,Clara K Chow,Shirley Pettit,S. Chrolavicius,Salim Yusuf,Salim Yusuf,Abstr Act,Abstr Act +45 more
TL;DR: Administration of aspirin before surgery and throughout the early postsurgical period had no significant effect on the rate of a composite of death or nonfatal myocardial infarction but increased the risk of major bleeding.
Journal ArticleDOI
Shift work and vascular events: systematic review and meta-analysis
Manav V. Vyas,Amit X. Garg,Arthur V. Iansavichus,John Costella,Allan Donner,Lars E. Laugsand,Imre Janszky,Marko Mrkobrada,Grace Parraga,Daniel G. Hackam +9 more
TL;DR: Shift work is associated with vascular events, which may have implications for public policy and occupational medicine, and pooled risk ratios were significant for both unadjusted analyses and analyses adjusted for risk factors.
Journal ArticleDOI
The statistical significance of randomized controlled trial results is frequently fragile: A case for a Fragility Index
Michael Walsh,Michael Walsh,Sadeesh Srinathan,Daniel F. McAuley,Marko Mrkobrada,Oren Levine,Christine Ribic,Amber O. Molnar,Neil D. Dattani,Andrew Burke,Gordon H. Guyatt,Lehana Thabane,Stephen D. Walter,Janice Pogue,Philip J. Devereaux,Philip J. Devereaux +15 more
TL;DR: The statistically significant results of many RCTs hinge on small numbers of events, and the Fragility Index complements the P-value and helps identify less robust results.