M
Markus Grompe
Researcher at Oregon Health & Science University
Publications - 323
Citations - 37404
Markus Grompe is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Fanconi anemia & Stem cell. The author has an hindex of 88, co-authored 313 publications receiving 34220 citations. Previous affiliations of Markus Grompe include Northwestern University & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Eric Lagasse,Heather Connors,Muhsen Al-Dhalimy,Michael J. Reitsma,Monika Dohse,Linda Osborne,Xin Wang,Milton J. Finegold,Irving L. Weissman,Markus Grompe +9 more
TL;DR: It is reported that intravenous injection of adult bone marrow cells in the FAH−/− mouse, an animal model of tyrosinemia type I, rescued the mouse and restored the biochemical function of its liver.
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Cell fusion is the principal source of bone-marrow-derived hepatocytes
Xin Wang,Holger Willenbring,Yassmine Akkari,Yumi Torimaru,Mark Foster,Muhsen Al-Dhalimy,Eric Lagasse,Milton J. Finegold,Susan B. Olson,Markus Grompe +9 more
TL;DR: It is concluded that hepatocytes derived form bone marrow arise from cell fusion and not by differentiation of haematopoietic stem cells.
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A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome
Carolyn J. Brown,Andrea Ballabio,James L. Rupert,Ronald G. Lafreniere,Markus Grompe,Rossana Tonlorenzi,Huntington F. Willard +6 more
TL;DR: This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation, and is described as an X-linked gene with a novel expression pattern.
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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway.
Irene García-Higuera,Toshiyasu Taniguchi,Shridar Ganesan,M. Stephen Meyn,Cynthia Timmers,James Hejna,Markus Grompe,Alan D. D'Andrea +7 more
TL;DR: The FANCD2 protein provides the missing link between the FA protein complex and the cellular BRCA1 repair machinery, and results in the cellular and clinical phenotype common to all FA subtypes.
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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Meritxell Huch,Craig Dorrell,Sylvia F. Boj,Johan H. van Es,Vivian S. W. Li,Marc van de Wetering,Toshiro Sato,Toshiro Sato,Karien Hamer,Nobuo Sasaki,Milton J. Finegold,Annelise Haft,Robert G.J. Vries,Markus Grompe,Hans Clevers +14 more
TL;DR: Findings indicate that previous observations concerning Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem Cells in a tissue with a low rate of spontaneous proliferation.