M
Meritxell Huch
Researcher at Max Planck Society
Publications - 80
Citations - 12896
Meritxell Huch is an academic researcher from Max Planck Society. The author has contributed to research in topics: Stem cell & Organoid. The author has an hindex of 34, co-authored 67 publications receiving 9728 citations. Previous affiliations of Meritxell Huch include Utrecht University & University Medical Center Utrecht.
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Journal ArticleDOI
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Sylvia F. Boj,Chang-Il Hwang,Chang-Il Hwang,Lindsey A. Baker,Lindsey A. Baker,Iok In Christine Chio,Iok In Christine Chio,Dannielle D. Engle,Dannielle D. Engle,Vincenzo Corbo,Vincenzo Corbo,Myrthe Jager,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Hervé Tiriac,Hervé Tiriac,Mona S. Spector,Mona S. Spector,Ana Gracanin,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Kenneth H. Yu,Ruben van Boxtel,Meritxell Huch,Keith Rivera,John P. Wilson,Michael E. Feigin,Michael E. Feigin,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Christine M. Ardito-Abraham,Christine M. Ardito-Abraham,Michael Ludwig,Michael Ludwig,Ela Elyada,Ela Elyada,Brinda Alagesan,Brinda Alagesan,Brinda Alagesan,Giulia Biffi,Giulia Biffi,Georgi N. Yordanov,Georgi N. Yordanov,Bethany Delcuze,Bethany Delcuze,Brianna Creighton,Brianna Creighton,Kevin Wright,Kevin Wright,Young-Kyu Park,Young-Kyu Park,Folkert H.M. Morsink,I. Quintus Molenaar,Inne H.M. Borel Rinkes,Edwin Cuppen,Yuan Hao,Ying Jin,Isaac J. Nijman,Christine A. Iacobuzio-Donahue,Steven D. Leach,Darryl J. Pappin,Molly Hammell,David S. Klimstra,Olca Basturk,Ralph H. Hruban,G. J. A. Offerhaus,Robert G.J. Vries,Hans Clevers,David A. Tuveson,David A. Tuveson,David A. Tuveson +73 more
TL;DR: Comprehensive transcriptional and proteomic analyses of murine pancreatic organoids revealed genes and pathways altered during disease progression that demonstrate that organoids are a facile model system to discover characteristics of this deadly malignancy.
Journal ArticleDOI
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Nick Barker,Meritxell Huch,Pekka Kujala,Marc van de Wetering,Hugo J. Snippert,Johan H. van Es,Toshiro Sato,Daniel E. Stange,Harry Begthel,Maaike van den Born,Esther Danenberg,Stieneke van den Brink,Jeroen Korving,Arie Abo,Peter J. Peters,Peter J. Peters,Nicholas A. Wright,Richard Poulsom,Hans Clevers +18 more
TL;DR: The Lgr5 stem cell marker and culture method described here will be invaluable tools for accelerating research into gastric epithelial renewal, inflammation/infection, and cancer.
Journal ArticleDOI
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
Meritxell Huch,Craig Dorrell,Sylvia F. Boj,Johan H. van Es,Vivian S. W. Li,Marc van de Wetering,Toshiro Sato,Toshiro Sato,Karien Hamer,Nobuo Sasaki,Milton J. Finegold,Annelise Haft,Robert G.J. Vries,Markus Grompe,Hans Clevers +14 more
TL;DR: Findings indicate that previous observations concerning Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem Cells in a tissue with a low rate of spontaneous proliferation.
Journal ArticleDOI
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Meritxell Huch,Helmuth Gehart,Ruben van Boxtel,Karien Hamer,Francis Blokzijl,Monique M A Verstegen,Ewa Ellis,Martien van Wenum,Sabine A. Fuchs,Joep de Ligt,Marc van de Wetering,Nobuo Sasaki,Susanne J. Boers,Hans Kemperman,Jeroen de Jonge,Jan N. M. IJzermans,Edward E. S. Nieuwenhuis,Ruurdtje Hoekstra,Stephen C. Strom,Robert R G Vries,Luc J. W. van der Laan,Edwin Cuppen,Hans Clevers +22 more
TL;DR: Conditions allowing long-term expansion of adult bile duct-derived bipotent progenitor cells from human liver opens up experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene therapy.
Journal ArticleDOI
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Laura Broutier,Gianmarco Mastrogiovanni,Monique M A Verstegen,Hayley E. Francies,Lena Morrill Gavarró,Charles R. Bradshaw,George E. Allen,Robert Arnes-Benito,Olga Sidorova,Marcia P. Gaspersz,Nikitas Georgakopoulos,Bon-Kyoung Koo,Sabine Dietmann,Susan E. Davies,Raaj K. Praseedom,Ruby Lieshout,Jan N. M. IJzermans,Stephen J. Wigmore,Kourosh Saeb-Parsy,Mathew J. Garnett,Luc J. W. van der Laan,Meritxell Huch +21 more
TL;DR: The wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease are demonstrated.