M
Markus Hoffmann
Researcher at German Primate Center
Publications - 155
Citations - 23747
Markus Hoffmann is an academic researcher from German Primate Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 103 publications receiving 14853 citations. Previous affiliations of Markus Hoffmann include University of Veterinary Medicine Hanover & University of Veterinary Medicine Vienna.
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Journal ArticleDOI
A surrogate cell-based SARS-CoV-2 spike blocking assay.
Wolfgang Schuh,Lena Baus,Tobit Steinmetz,Sebastian R. Schulz,Leonie Weckwerth,Edith Roth,Manuela Hauke,Sara Krause,Patrick Morhart,Manfred Rauh,Markus Hoffmann,Markus Hoffmann,Niklas Vesper,Michael Reth,Holm Schneider,Hans-Martin Jäck,Dirk Mielenz +16 more
TL;DR: In this article, a fast and inexpensive surrogate SARS-CoV-2 blocking assay (SUBA) was developed using immobilized recombinant human angiotensin-converting enzyme 2 (hACE2) and human cells expressing the native form of surface SARS CoV2 spike protein.
Posted ContentDOI
Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization
Dennis Lapuente,Jana Fuchs,Jonas Willar,Ana Vieira Antão,Valentina Everlein,Nadja Uhlig,Leila Issmail,Anna Schmidt,Friederike Oltmanns,Antonia Sophia Peter,Sandra Mueller-Schmucker,Pascal Irrgang,Kirsten Fraedrich,Andrea Cara,Markus Hoffmann,Markus Hoffmann,Stefan Poehlmann,Stefan Poehlmann,Armin Ensser,Cordula Pertl,Torsten Willert,Christian Thirion,Thomas Grunwald,Klaus Ueberla,Matthias Tenbusch +24 more
TL;DR: In this paper, the authors reported that intranasal vaccinations with adenovirus 5 and 19a vectored vaccines following a systemic DNA or mRNA priming result in strong systemic and mucosal immunity in mice.
Journal ArticleDOI
Reset of Inflammatory Priming of Joint Tissue and Reduction of the Severity of Arthritis Flares by Bromodomain Inhibition
Jasna Friščić,Christiane Reinwald,Martin Böttcher,Miranda Houtman,Maximilien Euler,Xi Chen,K. I. Walker,Philipp Kirchner,Honglin Zhu,Benjamin Wirth,Daniela Weidner,René Krüger,Vladimir Trajkovic,Arif B. Ekici,K Klein,Dimitrios Mougiakakos,Caroline Ospelt,Georg Schett,Markus Hoffmann +18 more
TL;DR: Inflammatory tissue priming is dependent on transcriptional regulation by BET proteins, which makes them promising therapeutic targets for preventing arthritis flares in previously affected joints.
Journal ArticleDOI
Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture
Lukas Wettstein,Philip Maximilian Knaff,Christian Kersten,Patrick Müller,Tanja Weil,Carina Conzelmann,Janis A. Müller,Maximilian Brückner,Markus Hoffmann,Stefan Pöhlmann,Tanja Schirmeister,Katharina Landfester,Jan Münch,Volker Mailänder +13 more
TL;DR: In this article , the authors describe the in-silico development and in vitro characterization of peptidomimetic transmembrane serine protease 2 (TMPRSS2) inhibitors and demonstrate good off-target selectivity against selected coagulation proteases.
Journal ArticleDOI
Mutagenic Analysis of the HIV Restriction Factor Shiftless
Niklas Jäger,Shreya Ahana Ayyub,Natalia Korniy,Frank Peske,Markus Hoffmann,Marina V. Rodnina,Stefan Pöhlmann +6 more
TL;DR: The results support the notion that SFL binds to the ribosome and the HIV RNA in order to block –1PRF and HIV infection, and suggest that the multimerization of SFL may be functionally important.