D
Daniela Weidner
Researcher at University of Erlangen-Nuremberg
Publications - 22
Citations - 1143
Daniela Weidner is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Inflammation & Neutrophil extracellular traps. The author has an hindex of 12, co-authored 17 publications receiving 648 citations.
Papers
More filters
Journal ArticleDOI
Locally renewing resident synovial macrophages provide a protective barrier for the joint
Stephan Culemann,Anika Grüneboom,José Ángel Nicolás-Ávila,Daniela Weidner,Katrin Franziska Lämmle,Tobias Rothe,Juan A. Quintana,Philipp Kirchner,Branislav Krljanac,Martin Eberhardt,Fulvia Ferrazzi,Elke Kretzschmar,Martin Schicht,Kim Fischer,Kolja Gelse,Maria Faas,R Pfeifle,Jochen A. Ackermann,Milena L Pachowsky,Nina Renner,David Simon,Reiner F. Haseloff,Arif B. Ekici,Tobias Bäuerle,Ingolf E. Blasig,Julio Vera,David Voehringer,Arnd Kleyer,Friedrich Paulsen,Georg Schett,Andrés Hidalgo,Gerhard Krönke +31 more
TL;DR: Analysis of macrophage subsets within joints reveals a population of CX3CR1+ tissue-resident macrophages that form a tight-junction-mediated barrier at the synovial lining, protecting the joint from the invasion of inflammatory cells.
Journal ArticleDOI
A network of trans-cortical capillaries as mainstay for blood circulation in long bones
Anika Grüneboom,Ibrahim Hawwari,Daniela Weidner,Stephan Culemann,Sylvia Müller,Sophie Henneberg,Alexandra Brenzel,Simon F. Merz,Lea Bornemann,Kristina Zec,Manuela Wuelling,Lasse Kling,Mike Hasenberg,Sylvia Voortmann,Stefanie C. Lang,Wolfgang Baum,Alexandra Ohs,Oliver Kraff,Harald H. Quick,Harald H. Quick,Marcus Jäger,Stefan Landgraeber,Marcel Dudda,Renzo Danuser,Jens V. Stein,Manfred Rohde,Kolja Gelse,Annette I. Garbe,Alexandra Adamczyk,Astrid M. Westendorf,Daniel Hoffmann,Silke Christiansen,Silke Christiansen,Daniel R. Engel,Andrea Vortkamp,Gerhard Krönke,Martin Herrmann,Thomas Kamradt,Georg Schett,Anja Hasenberg,Matthias Gunzer +40 more
TL;DR: Tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature are identified, and it is shown that the majority of blood in long bones passes through TCVs.
Journal ArticleDOI
Nanoparticles size-dependently initiate self-limiting NETosis-driven inflammation
Luis E. Muñoz,Rostyslav Bilyy,Mona H C Biermann,Deborah Kienhöfer,Christian Maueröder,Jonas Hahn,Jan Markus Brauner,Daniela Weidner,Jin Chen,Marina Scharin-Mehlmann,Christina Janko,Ralf P Friedrich,Dirk Mielenz,Tetiana Dumych,Maxim D. Lootsik,Christine Schauer,Georg Schett,Markus H. Hoffmann,Yi Zhao,Yi Zhao,Martin Herrmann +20 more
TL;DR: A cellular mechanism is demonstrated that explains how small NPs activate the NETosis pathway and drive their entrapping and resolution of the initial inflammatory response.
Journal ArticleDOI
Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
Jonas Hahn,Christine Schauer,Christine Czegley,Lasse Kling,Lenka Petru,Lenka Petru,Benjamin Schmid,Daniela Weidner,Christiane Reinwald,Mona H C Biermann,Stefan Blunder,Jurgen D. Ernst,Adam Lesner,Tobias Bäuerle,Ralf Palmisano,Silke Christiansen,Silke Christiansen,Silke Christiansen,Martin Herrmann,Aline Bozec,Robert Gruber,Georg Schett,Markus H. Hoffmann +22 more
TL;DR: Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases, as a built‐in safeguard for inflammation.
Journal ArticleDOI
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Jasna Friščić,Martin Böttcher,Christiane Reinwald,Heiko Bruns,Benjamin Wirth,Samantha-Josefine Popp,Kellie Irene Walker,Jochen A. Ackermann,Xi Chen,Jason D. Turner,Honglin Zhu,Honglin Zhu,Lisa Seyler,Maximilien Euler,Philipp Kirchner,René Krüger,Arif B. Ekici,Triin Major,Oliver Aust,Daniela Weidner,Anita Fischer,Fabian T. Andes,Zeljka Stanojevic,Vladimir Trajkovic,Martin Herrmann,Adelheid Korb-Pap,Isabel Wank,Andreas Hess,Johnathan Winter,Viktor Wixler,Jörg H W Distler,Günter Steiner,Hans P. Kiener,Benjamin Frey,Lasse Kling,Karim Raza,Silke Frey,Arnd Kleyer,Tobias Bäuerle,Timothy R. Hughes,Anika Grüneboom,Ulrike Steffen,Gerhard Krönke,Adam P. Croft,Andrew Filer,Jörg Köhl,Jörg Köhl,Katja Klein,Christopher D. Buckley,Christopher D. Buckley,Georg Schett,Dimitrios Mougiakakos,Markus H. Hoffmann +52 more
TL;DR: In this paper, the molecular and cellular mechanisms of inflammatory tissue priming are defined and the checkpoints between remission and persistence remain unknown. But, they suggest possibilities for therapeutic intervention abrogating tissue pre-priming without immunosuppression.