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Christiane Reinwald
Researcher at University of Erlangen-Nuremberg
Publications - 10
Citations - 663
Christiane Reinwald is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Inflammation & Neutrophil extracellular traps. The author has an hindex of 7, co-authored 9 publications receiving 426 citations.
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Journal ArticleDOI
To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps
Sebastian Boeltz,Poorya Amini,Hans-Joachim Anders,Felipe Andrade,Rostyslav Bilyy,Simon Chatfield,Iwona Cichon,Danielle M. Clancy,Jyaysi Desai,Tetiana Dumych,Nishant Dwivedi,Rachael A. Gordon,Jonas Hahn,Andrés Hidalgo,Andrés Hidalgo,Markus H. Hoffmann,Mariana J. Kaplan,Jason S. Knight,Elzbieta Kolaczkowska,Paul Kubes,Moritz Leppkes,Angelo A. Manfredi,Seamus J. Martin,Christian Maueröder,Christian Maueröder,Norma Maugeri,Ioannis Mitroulis,Luis E. Muñoz,Daigo Nakazawa,Indira Neeli,Victor Nizet,Elmar Pieterse,Marko Z. Radic,Christiane Reinwald,Konstantinos Ritis,Patrizia Rovere-Querini,Michal Santocki,Christine Schauer,Georg Schett,Mark J. Shlomchik,Hans-Uwe Simon,Hans-Uwe Simon,Panagiotis Skendros,Darko Stojkov,Peter Vandenabeele,Tom Vanden Berghe,Tom Vanden Berghe,Johan van der Vlag,Ljubomir Vitkov,Ljubomir Vitkov,Maren von Köckritz-Blickwede,Shida Yousefi,Alexander Zarbock,Martin Herrmann +53 more
TL;DR: In this paper, the authors present prevailing concepts and state of the science in neutrophil extracellular traps (NET) related research and elaborate on open questions and areas of dispute.
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Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps
Deborah Kienhöfer,Jonas Hahn,Julia Stoof,Janka Zsófia Csepregi,Christiane Reinwald,Vilma Urbonaviciute,Caroline Johnsson,Christian Maueröder,Malgorzata J. Podolska,Mona H C Biermann,Moritz Leppkes,Thomas Harrer,Malin Hultqvist,Peter Olofsson,Luis E. Muñoz,Attila Mócsai,Martin Herrmann,Georg Schett,Rikard Holmdahl,Markus H. Hoffmann +19 more
TL;DR: The findings suggest that aberrant NET is one of the factors promoting experimental lupus-like autoimmunity by uncontrolled release of inflammatory mediators.
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Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases
Jonas Hahn,Christine Schauer,Christine Czegley,Lasse Kling,Lenka Petru,Lenka Petru,Benjamin Schmid,Daniela Weidner,Christiane Reinwald,Mona H C Biermann,Stefan Blunder,Jurgen D. Ernst,Adam Lesner,Tobias Bäuerle,Ralf Palmisano,Silke Christiansen,Silke Christiansen,Silke Christiansen,Martin Herrmann,Aline Bozec,Robert Gruber,Georg Schett,Markus H. Hoffmann +22 more
TL;DR: Aggregated neutrophil extracellular traps resolve inflammation by proteolysis of cytokines and chemokines and protection from antiproteases, as a built‐in safeguard for inflammation.
Journal ArticleDOI
The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts.
Jasna Friščić,Martin Böttcher,Christiane Reinwald,Heiko Bruns,Benjamin Wirth,Samantha-Josefine Popp,Kellie Irene Walker,Jochen A. Ackermann,Xi Chen,Jason D. Turner,Honglin Zhu,Honglin Zhu,Lisa Seyler,Maximilien Euler,Philipp Kirchner,René Krüger,Arif B. Ekici,Triin Major,Oliver Aust,Daniela Weidner,Anita Fischer,Fabian T. Andes,Zeljka Stanojevic,Vladimir Trajkovic,Martin Herrmann,Adelheid Korb-Pap,Isabel Wank,Andreas Hess,Johnathan Winter,Viktor Wixler,Jörg H W Distler,Günter Steiner,Hans P. Kiener,Benjamin Frey,Lasse Kling,Karim Raza,Silke Frey,Arnd Kleyer,Tobias Bäuerle,Timothy R. Hughes,Anika Grüneboom,Ulrike Steffen,Gerhard Krönke,Adam P. Croft,Andrew Filer,Jörg Köhl,Jörg Köhl,Katja Klein,Christopher D. Buckley,Christopher D. Buckley,Georg Schett,Dimitrios Mougiakakos,Markus H. Hoffmann +52 more
TL;DR: In this paper, the molecular and cellular mechanisms of inflammatory tissue priming are defined and the checkpoints between remission and persistence remain unknown. But, they suggest possibilities for therapeutic intervention abrogating tissue pre-priming without immunosuppression.
Journal ArticleDOI
Oxidative Burst-Dependent NETosis Is Implicated in the Resolution of Necrosis-Associated Sterile Inflammation.
Mona Helena Biermann,Malgorzata J. Podolska,Jasmin Knopf,Christiane Reinwald,Daniela Weidner,Christian Maueröder,Jonas Hahn,Deborah Kienhöfer,Alexandre Barras,Rabah Boukherroub,Sabine Szunerits,Rostyslav Bilyy,Markus H. Hoffmann,Yi Zhao,Georg Schett,Martin Herrmann,Luis E. Muñoz +16 more
TL;DR: It is observed that Ncf1** mice deficient in NADPH-dependent ROS failed to generate granulation tissue therefore being unable to trap the nanodiamonds, suggesting that NOX2-dependent NETosis is crucial for preventing the chronification of the inflammatory response to tissue necrosis by forming NETosis-dependent barriers between the necrotic and healthy surrounding tissue.