M
Markus Hoffmann
Researcher at German Primate Center
Publications - 155
Citations - 23747
Markus Hoffmann is an academic researcher from German Primate Center. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 103 publications receiving 14853 citations. Previous affiliations of Markus Hoffmann include University of Veterinary Medicine Hanover & University of Veterinary Medicine Vienna.
Papers
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Journal ArticleDOI
B.1.617.2 enters and fuses lung cells with increased efficiency and evades antibodies induced by infection and vaccination.
Prerna Arora,Prerna Arora,Anzhalika Sidarovich,Anzhalika Sidarovich,Nadine Krüger,Amy Kempf,Amy Kempf,Inga Nehlmeier,Luise Graichen,Luise Graichen,Anna-Sophie Moldenhauer,Martin Sebastian Winkler,Sebastian R. Schulz,Hans-Martin Jäck,Metodi V. Stankov,Georg M. N. Behrens,Stefan Pöhlmann,Stefan Pöhlmann,Markus Hoffmann,Markus Hoffmann +19 more
TL;DR: In this article, the Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), B.1.617.2, was identified as an immune evasion variant with increased capacity to enter and fuse lung cells.
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The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant
Prerna Arora,Lu Zhang,Cheila Rocha,Luise Graichen,Inga Nehlmeier,Amy Kempf,Anne Cossmann,Gema Morillas Ramos,Eva Baier,Björn Tampe,Onnen Moerer,Steffen Dickel,Martin Sebastian Winkler,G. Behrens,Stefan Pöhlmann,Markus Hoffmann +15 more
TL;DR: In this article , a recombinant SARS-CoV-2 lineage, XD, emerged that harbors a spike gene that is largely derived from the Omicron variant BA.1 in the genetic background of the Delta variant.
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Targeting the tissue-complosome for curbing inflammatory disease.
TL;DR: In this paper , an overview on complement activation and inflammatory transformation in tissue-occupying cells, focusing on fibroblasts during arthritis, and illustrate ways how therapeutics directed at complement C3 could potentially target the complosome to unprime cells in the tissue and induce long-lasting abatement of inflammation.
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Understanding Omicron: Transmissibility, immune evasion and antiviral intervention
TL;DR: This work comments on host cell interactions governing cell entry of the Omicron variant and their implications for transmissibility, virulence, immune evasion, and therapeutic options, and focuses on the viral spike protein, which facilitates viral entry into cells and is the key target of the neutralizing antibody response.
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SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications
Anja Schlör,Sandra Hirschberg,Golsom Ben Amor,Toni Luise Meister,P. Arora,Stefan Pöhlmann,Markus Hoffmann,Stephanie Pfaender,O. Kamal Eddin,Julian Kamhieh-Milz,Katja Hanack +10 more
TL;DR: Novel camelid heavy-chain-only antibodies (hcAb) are described as useful for novel in vitro diagnostic assays and for therapeutic applications due to their neutralizing capacity.