M
Marlena Kowalska
Researcher at Technische Universität München
Publications - 3
Citations - 301
Marlena Kowalska is an academic researcher from Technische Universität München. The author has contributed to research in topics: Metastasis & Pancreatic cancer. The author has an hindex of 2, co-authored 3 publications receiving 198 citations.
Papers
More filters
Journal ArticleDOI
Mutant KRAS -driven cancers depend on PTPN11 /SHP2 phosphatase
Dietrich A. Ruess,Dietrich A. Ruess,Guus J.J.E. Heynen,Katrin J. Ciecielski,Jiaoyu Ai,Alexandra Berninger,Derya Kabacaoglu,Kivanc Görgülü,Zahra Dantes,S Wörmann,Kalliope N. Diakopoulos,Angeliki Faidra Karpathaki,Marlena Kowalska,Ezgi Kaya-Aksoy,Liang Song,Eveline A.N. Zeeuw van der Laan,María P. López-Alberca,Marc Nazaré,Maximilian Reichert,Dieter Saur,Mert Erkan,Ulrich T. Hopt,Bruno Sainz,Walter Birchmeier,Roland M. Schmid,Marina Lesina,Hana Algül +26 more
TL;DR: The data indicate the clinical utility of dual SHP2/MEK inhibition as a targeted therapy approach for KRAS-mutant cancers and provide evidence for a critical dependence of mutant KRAS on SHp2 during carcinogenesis.
Journal ArticleDOI
Levels of the Autophagy-Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
Kivanc Görgülü,Kalliope N. Diakopoulos,Jiaoyu Ai,Benjamin Schoeps,Derya Kabacaoglu,Angeliki Faidra Karpathaki,Katrin J. Ciecielski,Ezgi Kaya-Aksoy,Dietrich A. Ruess,Alexandra Berninger,Marlena Kowalska,Marija Stevanovic,S Wörmann,Thomas Wartmann,Yue Zhao,Walter Halangk,Svetlana Voronina,A. V. Tepikin,Anna Melissa Schlitter,Katja Steiger,Anna Artati,Jerzy Adamski,Michaela Aichler,Axel Walch,Martin Jastroch,Götz Hartleben,Christos S. Mantzoros,Wilko Weichert,Roland M. Schmid,Stephan Herzig,Achim Krüger,Bruno Sainz,Marina Lesina,Hana Algül +33 more
TL;DR: In mice that express oncogenic Kras in pancreatic cells, heterozygous disruption of Atg5 and reduced protein levels promotes tumor development, whereas homozygous disruptions of AtG5 blocks tumorigenesis.
Journal ArticleDOI
Bcl3 Couples Cancer Stem Cell Enrichment With Pancreatic Cancer Molecular Subtypes.
Jiaoyu Ai,S Wörmann,S Wörmann,Kivanc Görgülü,Mireia Vallespinós,Sladjana Zagorac,Sladjana Zagorac,Sonia Alcalá,Nan Wu,Derya Kabacaoglu,Alexandra Berninger,Diego Navarro,Ezgi Kaya-Aksoy,Dietrich A. Ruess,Dietrich A. Ruess,Katrin J. Ciecielski,Marlena Kowalska,Ihsan Ekin Demir,Güralp O. Ceyhan,Irina Heid,Rickmer Braren,Marc Riemann,Sabrina Schreiner,Samuel Hofmann,Maria Kutschke,Martin Jastroch,Julia Slotta-Huspenina,Alexander Muckenhuber,Anna Melissa Schlitter,Roland M. Schmid,Katja Steiger,Kalliope N. Diakopoulos,Marina Lesina,Bruno Sainz,Hana Algül +34 more
TL;DR: In this article, the authors identified B-cell CLL/lymphoma 3 (BCL3), an atypical nf-κb signaling member, as differing in pancreatic CSCs.