J
Janet J. Maguire
Researcher at University of Cambridge
Publications - 148
Citations - 7273
Janet J. Maguire is an academic researcher from University of Cambridge. The author has contributed to research in topics: Receptor & Endothelin receptor. The author has an hindex of 44, co-authored 133 publications receiving 6267 citations. Previous affiliations of Janet J. Maguire include British Heart Foundation & University College London.
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Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis
Murray C.H. Clarke,Nichola Figg,Janet J. Maguire,Anthony P. Davenport,Martin Goddard,Trevor D. Littlewood,Martin R. Bennett +6 more
TL;DR: It is concluded that VSMC apoptosis is 'silent' in normal arteries, which have a large capacity to withstand cell loss, and that SM22α-hDTR Apoe−/− mice may represent an important new model to test agents proposed to stabilize atherosclerotic plaques.
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Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration
Murray C.H. Clarke,Trevor D. Littlewood,Nichola Figg,Janet J. Maguire,Anthony P. Davenport,Martin Goddard,Martin R. Bennett +6 more
TL;DR: It is concluded that VSMC apoptosis is sufficient to accelerate Atherosclerosis, promote plaque calcification and medial degeneration, prevent expansive remodeling, and promote stenosis in atherosclerosis.
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[Pyr1]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart. Vasoactive Mechanisms and Inotropic Action in Disease
TL;DR: It is demonstrated that the 3 principal forms of apelin have comparable potency and efficacy in human cardiovascular tissues for the first time.
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Orphan-receptor ligand human urotensin II: receptor localization in human tissues and comparison of vasoconstrictor responses with endothelin-1
TL;DR: The distribution of receptors for human urotensin‐II (U‐II) in human and rat CNS and peripheral tissues is determined and a potential role for U‐II in human physiology is suggested.
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors
Stephen P.H. Alexander,Arthur Christopoulos,Anthony P. Davenport,Eamonn Kelly,Alistair Mathie,John A. Peters,Emma L. Veale,Jane F. Armstrong,Elena Faccenda,Simon D. Harding,Adam J. Pawson,Christopher Southan,Jamie A. Davies,Maria P. Abbracchio,Wayne R. Alexander,Khaled A. Al-Hosaini,Magnus Bäck,Nicholas M. Barnes,Ross A. D. Bathgate,Jean-Martin Beaulieu,Kenneth E. Bernstein,Bernhard Bettler,Nigel J. M. Birdsall,Victoria A. Blaho,François Boulay,Corinne Bousquet,Hans Bräuner-Osborne,Geoffrey Burnstock,Girolamo Calò,Justo P. Castaño,Kevin J. Catt,Stefania Ceruti,Paul L. Chazot,Nan Chiang,Bice Chini,Jerold Chun,Antonia Cianciulli,Olivier Civelli,Lucie H. Clapp,Réjean Couture,Zsolt Csaba,Claes Dahlgren,Gordon Dent,Khuraijam Dhanachandra Singh,Steven D. Douglas,Pascal Dournaud,Satoru Eguchi,Emanuel Escher,Edward J. Filardo,Tung Fong,Marta Fumagalli,Raul R. Gainetdinov,Marc de Gasparo,Craig Gerard,Marvin C. Gershengorn,Fernand Gobeil,Theodore L. Goodfriend,Cyril Goudet,Karen J. Gregory,Andrew L. Gundlach,Jörg Hamann,Julien Hanson,Richard L. Hauger,Debbie L. Hay,Akos Heinemann,Morley D. Hollenberg,Nicholas D. Holliday,Mastgugu Horiuchi,Daniel Hoyer,László Hunyady,Ahsan Husain,Adriaan P. IJzerman,Tadashi Inagami,Kenneth A. Jacobson,Robert T. Jensen,Ralf Jockers,Deepa Jonnalagadda,Sadashiva S. Karnik,Klemens Kaupmann,Jacqueline R. Kemp,Charles Kennedy,Yasuyuki Kihara,Takio Kitazawa,Paweł Kozielewicz,Hans-Jürgen Kreienkamp,Jyrki P. Kukkonen,Tobias Langenhan,Katie Leach,Davide Lecca,John D. Lee,Susan E. Leeman,Jérôme Leprince,Xaria X. Li,Thomas L Williams,Stephen J Lolait,Amelie Lupp,Robyn Macrae,Janet J. Maguire,Jean Mazella,Craig A. McArdle,Shlomo Melmed,Martin C. Michel,Laurence J. Miller,Vincenzo Mitolo,Bernard Mouillac,Christa E. Müller,Philip N. Murphy,Jean-Louis Nahon,Tony Ngo,Xavier Norel,Duuamene Nyimanu,Anne Marie O'Carroll,Stefan Offermanns,Maria Antonietta Panaro,Marc Parmentier,Roger G. Pertwee,Jean-Philippe Pin,Eric R. Prossnitz,Mark T. Quinn,Rithwik Ramachandran,Manisha Ray,Rainer K. Reinscheid,Philippe Rondard,G. Enrico Rovati,Chiara Ruzza,Gareth J. Sanger,Torsten Schöneberg,Gunnar Schulte,Stefan Schulz,Deborah L. Segaloff,Charles N. Serhan,Leigh A. Stoddart,Yukihiko Sugimoto,Roger J. Summers,Valerie P. Tan,David M. Thal,Walter G. Thomas,Pieter Timmermans,Kalyan C. Tirupula,Giovanni Tulipano,Hamiyet Unal,Thomas Unger,Celine Valant,Patrick Vanderheyden,David Vaudry,Hubert Vaudry,Jean-Pierre Vilardaga,Christopher S. Walker,Ji Ming Wang,Donald T. Ward,Hans-Jürgen Wester,Gary B. Willars,Trent M. Woodruff,Chengcan Yao,Richard D. Ye +154 more
TL;DR: The Concise Guide to PHARMACOLOGY 2021/22 as mentioned in this paper provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands.