M
Mary Anne Enoch
Researcher at National Institutes of Health
Publications - 12
Citations - 996
Mary Anne Enoch is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Dopaminergic & Harm avoidance. The author has an hindex of 11, co-authored 12 publications receiving 910 citations. Previous affiliations of Mary Anne Enoch include University of Oklahoma Health Sciences Center.
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Journal ArticleDOI
Genetic variation in human NPY expression affects stress response and emotion
Zhifeng Zhou,Guanshan Zhu,Guanshan Zhu,Ahmad R. Hariri,Mary Anne Enoch,D. Scott,Rajita Sinha,Matti Virkkunen,Deborah C. Mash,Robert H. Lipsky,Xian Zhang Hu,Colin A. Hodgkinson,Ke Xu,Beata Buzas,Qiaoping Yuan,Pei Hong Shen,Robert E. Ferrell,Stephen B. Manuck,Sarah M. Brown,Richard L. Hauger,Christian S. Stohler,Jon Kar Zubieta,David Goldman +22 more
TL;DR: It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress.
Journal ArticleDOI
Loss of metabotropic glutamate receptor 2 escalates alcohol consumption
Zhifeng Zhou,Camilla Karlsson,Tiebing Liang,Wei Xiong,Mitsuru Kimura,Jenica D. Tapocik,Qiaoping Yuan,Estelle Barbier,Austin Y. Feng,Meghan E. Flanigan,Eric Augier,Mary Anne Enoch,Colin A. Hodgkinson,Pei Hong Shen,David M. Lovinger,Howard J. Edenberg,Markus Heilig,David Goldman +17 more
TL;DR: Genetic variation of Grm2, which encodes metabotropic glutamate receptor 2 (mGluR2), alters alcohol preference in animal models and is identified as an origin of alcohol preference and a potential therapeutic target.
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Oxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex-Dependent Manner
Tiffany M. Love,Mary Anne Enoch,Colin A. Hodgkinson,Marta Peciña,Brian J. Mickey,Brian J. Mickey,Robert A. Koeppe,Christian S. Stohler,David Goldman,Jon Kar Zubieta,Jon Kar Zubieta +10 more
TL;DR: In this article, the authors examined how genetic variation within the oxytocin gene (OXT) is associated with stress-induced dopaminergic neurotransmission in a healthy human sample and found that female GG homozygotes exhibited higher attachment anxiety, higher trait anxiety and lower emotional well-being scores.
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GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
TL;DR: This study confirms the involvement of the GABAergic system in alcoholism but also reveals a hippocampal GABA input in cocaine addiction and provides clues to predisposing factors for alcohol and drug addiction.
Journal ArticleDOI
Variation in the Corticotropin-Releasing Hormone Receptor 1 (CRHR1) Gene Influences fMRI Signal Responses during Emotional Stimulus Processing
David T. Hsu,Brian J. Mickey,Scott A. Langenecker,Mary M. Heitzeg,Tiffany M. Love,Heng Wang,Susan E. Kennedy,Marta Peciña,Tal Shafir,Colin A. Hodgkinson,Mary Anne Enoch,David Goldman,Jon Kar Zubieta +12 more
TL;DR: Results from healthy controls and a preliminary sample of MDD participants show that CRHR1 single nucleotide polymorphism rs110402 moderates neural responses to emotional stimuli, suggesting a potential mechanism of vulnerability for the development of major depressive disorder.