M
Masahiro Nomoto
Researcher at Ehime University
Publications - 110
Citations - 1799
Masahiro Nomoto is an academic researcher from Ehime University. The author has contributed to research in topics: Parkinson's disease & Levodopa. The author has an hindex of 19, co-authored 102 publications receiving 1459 citations.
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Journal ArticleDOI
Levodopa-induced dyskinesias.
Giovanni Fabbrini,Jonathan M. Brotchie,Francisco Grandas,Masahiro Nomoto,Christopher G. Goetz +4 more
TL;DR: This review focuses on three issues related to Levodopa‐induced dyskinesia: clinical features, classification and rating, pathophysiology and pathogenesis, and management.
Journal ArticleDOI
Amantadine for dyskinesias in Parkinson's disease: a randomized controlled trial.
Hideyuki Sawada,Tomoko Oeda,Sadako Kuno,Masahiro Nomoto,Kenji Yamamoto,Mitsutoshi Yamamoto,Kinya Hisanaga,Takashi Kawamura +7 more
TL;DR: Results from the present study demonstrated that amantadine exhibited efficacious effects against dyskinesias in 60–70% of patients.
Journal ArticleDOI
ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19
Yuji Takahashi,Yoko Fukuda,Jun Yoshimura,Atsushi Toyoda,Kari J. Kurppa,Hiroyoko Moritoyo,Veronique V. Belzil,Patrick A. Dion,Patrick A. Dion,Koichiro Higasa,Koichiro Doi,Hiroyuki Ishiura,Jun Mitsui,Hidetoshi Date,Budrul Ahsan,Takashi Matsukawa,Yaeko Ichikawa,Takashi Moritoyo,Mayumi Ikoma,Tsukasa Hashimoto,Fumiharu Kimura,Shigeo Murayama,Osamu Onodera,Masatoyo Nishizawa,Mari Yoshida,Naoki Atsuta,Gen Sobue,Jennifer A. Fifita,Jennifer A. Fifita,Kelly L. Williams,Kelly L. Williams,Ian P. Blair,Ian P. Blair,Garth A. Nicholson,Paloma Gonzalez-Perez,Robert H. Brown,Masahiro Nomoto,Klaus Elenius,Klaus Elenius,Guy A. Rouleau,Guy A. Rouleau,Guy A. Rouleau,Asao Fujiyama,Shinichi Morishita,Jun Goto,Shoji Tsuji +45 more
TL;DR: It is indicated that disruption of the neuregulin-ErbBB4 pathway is involved in the pathogenesis of ALS and potentially paves the way for the development of innovative therapeutic strategies such using NRGs or their agonists to upregulate ErbB4 functions.
Journal ArticleDOI
Phagocytic elimination of synapses by microglia during sleep.
Mohammed E. Choudhury,Kazuya Miyanishi,Haruna Takeda,Afsana Islam,Nayu Matsuoka,Madoka Kubo,Shirabe Matsumoto,Takeharu Kunieda,Masahiro Nomoto,Hajime Yano,Junya Tanaka +10 more
TL;DR: It is suggested that microglia may eliminate presumably weak synapses during every sleep phase, and the circadian changes in concentrations of circulating glucocorticoids and brain NA might be correlated with thecircadian changes of microglial phenotypes and synaptic strength.
Journal ArticleDOI
Antinociceptive mechanism of l-DOPA
TL;DR: It is suggested that l‐DOPA relieves pain after conversion to dopamine, with the dopamine sedating pain transmission by way of the dopamine D2 receptor, which is antagonized by sulpiride, a D2 blocker, but not by SCH 23390, aD1 blocker.