Kunihito Gotoh

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: The whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in H CCs.

TL;DR: In this article, a comprehensive analysis identified point mutations, structural variations (STVs), and virus integrations, in noncoding and coding regions of 300 liver cancers from Japanese individuals.

TL;DR: It is shown that Atg7, a gene essential for autophagy induction, is a critical mediator of H/I-induced neuron death and represents an attractive therapeutic target for minimizing the neurological deficits associated with H/ I brain injury.

TL;DR: A novel indocyanine green (ICG) fluorescence imaging technique is presented to visualize hepatocellular carcinoma (HCC) and shows clear delineation between tumor and normal tissue.