M
Masashi Fukayama
Researcher at National Institutes of Health
Publications - 3
Citations - 2134
Masashi Fukayama is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Respiratory epithelium & Messenger RNA. The author has an hindex of 3, co-authored 3 publications receiving 2119 citations.
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Journal ArticleDOI
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
Melissa A. Rosenfeld,Kunihiko Yoshimura,Bruce C. Trapnell,Koichi Yoneyama,Eugene Rosenthal,Wilfried Dalemans,Masashi Fukayama,Joachim Bargon,L Stier,Leslie Stratford-Perricaudet,Michel Perricaudet,William B. Guggino,Andrea Pavirani,J P Lecocq,Ronald G. Crystal +14 more
TL;DR: Observations suggest the feasibility of in vivo CFTR gene transfer as therapy for the pulmonary manifestations of CF.
Journal ArticleDOI
Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo
Melissa A. Rosenfeld,Wolfgang Siegfried,Kunihiko Yoshimura,Koichi Yoneyama,Masashi Fukayama,L Stier,Paavo K. Paakko,Pascale Gilardi,L D Stratford-Perricaudet,Michel Perricaudet,Sophie Jallat,Andrea Pavirani,Jean-Pierre Lecocq,Ronald G. Crystal +13 more
TL;DR: The respiratory epithelium is a potential site for somatic gene therapy for the common hereditary disorders alpha 1-antitrypsin (alpha 1AT) deficiency and cystic fibrosis by infecting epithelial cells of the cotton rat respiratory tract in vitro and in vivo.
Journal ArticleDOI
Respiratory tract gene transfer. Transplantation of genetically modified T-lymphocytes directly to the respiratory epithelial surface.
TL;DR: It is suggested that direct transplantation of genetically modified T-cells into the lung is feasible and represents a viable strategy for lung-specific gene transfer and the number of Thy1.2+ beta-gal+ T- cells in the lung could be modified by the systemic administration of IL-2.