Massimo Santoro

TL;DR: A novel activated oncogene resulted from the rearrangement of an unknown amino-terminal sequence to the tyrosine kinase domain of the ret proto-oncogene and was detected by transfection analysis in five out of 20 primary human thyroid papillary carcinomas and in the available lymph node metastases.

TL;DR: How the mitochondria has a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells is described, and the potential therapeutic use of agents that directly or indirectly block metabolism is discussed.

TL;DR: It is demonstrated that the serine/threonine kinase Akt regulates cell proliferation in breast cancer cells by preventing p27kip1-mediated growth arrest and cytoplasmic relocalization of p27Kip1, secondary to Akt-mediated phosphorylation, is a novel mechanism whereby the growth inhibitory properties of p 27kip 1 are functionally inactivated and the proliferation of breast cancer Cells is sustained.

TL;DR: Findings in wound biology clarified the molecular pathways governing keratinocyte reepithelization at wound sites point towards novel therapeutic targets and provide suitable methods to promote faster tissue regeneration in vivo.

TL;DR: The data suggest that BRAF V600E mutation is associated with high-risk PTC and in particular in follicular variant with invasive tumor growth.