M
Massimo Santoro
Researcher at University of Turin
Publications - 185
Citations - 15848
Massimo Santoro is an academic researcher from University of Turin. The author has contributed to research in topics: Thyroid carcinoma & Thyroid. The author has an hindex of 66, co-authored 173 publications receiving 14778 citations. Previous affiliations of Massimo Santoro include Flanders Institute for Biotechnology & University of Eastern Piedmont.
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Journal ArticleDOI
PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas.
M. Grieco,Massimo Santoro,Maria Teresa Berlingieri,Rosa Marina Melillo,R. Donghi,Italia Bongarzone,Marco A. Pierotti,Giuseppe Della Ports,Alfredo Fusco,Giancarlo Vecchiot +9 more
TL;DR: A novel activated oncogene resulted from the rearrangement of an unknown amino-terminal sequence to the tyrosine kinase domain of the ret proto-oncogene and was detected by transfection analysis in five out of 20 primary human thyroid papillary carcinomas and in the available lymph node metastases.
Journal ArticleDOI
ROS homeostasis and metabolism: a dangerous liason in cancer cells.
TL;DR: How the mitochondria has a key role in regulating the interplay between redox homeostasis and metabolism within tumor cells is described, and the potential therapeutic use of agents that directly or indirectly block metabolism is discussed.
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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27 Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
Giuseppe Viglietto,Maria Letizia Motti,Paola Bruni,Rosa Marina Melillo,A D'Alessio,Daniela Califano,Floriana Vinci,Gennaro Chiappetta,Philip N. Tsichlis,Alfonso Bellacosa,Alfonso Bellacosa,Alfredo Fusco,Massimo Santoro +12 more
TL;DR: It is demonstrated that the serine/threonine kinase Akt regulates cell proliferation in breast cancer cells by preventing p27kip1-mediated growth arrest and cytoplasmic relocalization of p27Kip1, secondary to Akt-mediated phosphorylation, is a novel mechanism whereby the growth inhibitory properties of p 27kip 1 are functionally inactivated and the proliferation of breast cancer Cells is sustained.
Journal ArticleDOI
Cellular and molecular facets of keratinocyte reepithelization during wound healing
Massimo Santoro,Giovanni Gaudino +1 more
TL;DR: Findings in wound biology clarified the molecular pathways governing keratinocyte reepithelization at wound sites point towards novel therapeutic targets and provide suitable methods to promote faster tissue regeneration in vivo.
Journal ArticleDOI
Association of BRAF V600E Mutation with Poor Clinicopathological Outcomes in 500 Consecutive Cases of Papillary Thyroid Carcinoma
Cristiana Lupi,Riccardo Giannini,Clara Ugolini,Agnese Proietti,Piero Berti,Michele Minuto,Gabriele Materazzi,Rossella Elisei,Massimo Santoro,Paolo Miccoli,Fulvio Basolo +10 more
TL;DR: The data suggest that BRAF V600E mutation is associated with high-risk PTC and in particular in follicular variant with invasive tumor growth.