Journal ArticleDOI
The Yin and Yang of type I interferon activity in bacterial infection
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TLDR
An increasing body of work shows that type I IFNs have an important role in the host response to bacterial infection, and can influence various immune effector mechanisms.Abstract:
Interferons (IFNs) are cytokines that are important for immune responses, particularly to intracellular pathogens. They are divided into two structurally and functionally distinct types that interact with different cell-surface receptors. Classically, type I IFNs are potent antiviral immunoregulators, whereas the type II IFN enhances antibacterial immunity. However, as outlined here, type I IFNs are also produced in response to infection with other pathogens, and an increasing body of work shows that type I IFNs have an important role in the host response to bacterial infection. Strikingly, their activity can be either favourable or detrimental, and can influence various immune effector mechanisms.read more
Citations
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Journal ArticleDOI
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
TL;DR: This review presents current knowledge on pathogen recognition through different families of PRRs and the increasingly complex signaling pathways responsible for activation of an inflammatory and antimicrobial response and medical implications are discussed.
Journal ArticleDOI
An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis
Matthew Berry,Christine M. Graham,Finlay W. McNab,Zhaohui Xu,Susannah Bloch,Tolu Oni,Tolu Oni,Katalin A. Wilkinson,Katalin A. Wilkinson,Romain Banchereau,Jason A. Skinner,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Charles T. Quinn,Derek Blankenship,Ranju Dhawan,John J. Cush,Asuncion Mejias,Octavio Ramilo,Onn Min Kon,Virginia Pascual,Jacques Banchereau,Damien Chaussabel,Anne O'Garra +24 more
TL;DR: A hitherto underappreciated role of type I IFN-αβ signalling in the pathogenesis of TB is demonstrated, which has implications for vaccine and therapeutic development and a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic are provided.
Journal ArticleDOI
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Kenya Honda,Tadatsugu Taniguchi +1 more
TL;DR: The interferon-regulatory factor family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons but has now been shown to have functionally diverse roles in the regulation of the immune system.
Book ChapterDOI
Regulation of interferon-gamma during innate and adaptive immune responses.
TL;DR: The epigenetic modifications and three-dimensional structure of the Ifng locus in naive CD4 T cells, and the modifications they undergo as these cells differentiate into effector T cells suggest a model whereby the chromatin architecture of Ifng is poised to facilitate either rapid opening or silencing during Th1 or Th2 differentiation, respectively.
Journal ArticleDOI
Interferons, immunity and cancer immunoediting.
TL;DR: The roles of the IFNs are discussed, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.
References
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Journal ArticleDOI
Toll-like receptor signalling
Shizuo Akira,Kiyoshi Takeda +1 more
TL;DR: Rapid progress that has recently improved the understanding of the molecular mechanisms that mediate TLR signalling is reviewed.
Journal ArticleDOI
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
Journal ArticleDOI
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
TL;DR: A previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that phosphorylate substrate proteins called STATs (signal transducers and activators of transcription).
Journal ArticleDOI
How cells respond to interferons
TL;DR: The Janus kinases and signal transducers and activators of transcription, and many of the interferon-induced proteins, play important alternative roles in cells, raising interesting questions as to how the responses to the interFERons intersect with more general aspects of cellular physiology and how the specificity of cytokine responses is maintained.
Journal ArticleDOI
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Mitsutoshi Yoneyama,Mika Kikuchi,Takashi Natsukawa,Noriaki Shinobu,Tadaatsu Imaizumi,Makoto Miyagishi,Kazunari Taira,Shizuo Akira,Takashi Fujita +8 more
TL;DR: In this article, the authors identify retinoic acid inducible gene I (RIG-I), which encodes a DExD/H box RNA helicase that contains a caspase recruitment domain, as an essential regulator for dsRNA-induced signaling.