Z
Zhen W. Zhuang
Researcher at Yale University
Publications - 60
Citations - 4629
Zhen W. Zhuang is an academic researcher from Yale University. The author has contributed to research in topics: Arteriogenesis & Angiogenesis. The author has an hindex of 32, co-authored 59 publications receiving 4037 citations. Previous affiliations of Zhen W. Zhuang include Dartmouth–Hitchcock Medical Center & Eli Lilly and Company.
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Journal ArticleDOI
Tissue-Engineered Lungs for in Vivo Implantation
Thomas Petersen,Elizabeth A. Calle,Liping Zhao,Eun Jung Lee,Liqiong Gui,Micha Sam Brickman Raredon,Kseniya Gavrilov,Tai Yi,Zhen W. Zhuang,Christopher K. Breuer,Erica L. Herzog,Laura E. Niklason +11 more
TL;DR: Treating lungs from adult rats using a procedure that removes cellular components but leaves behind a scaffold of extracellular matrix suggests that repopulation of lung matrix is a viable strategy for lung regeneration.
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Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
Yukiji Takeda,Sandra Costa,Estelle Delamarre,Carmen Roncal,Rodrigo Leite de Oliveira,Mario Leonardo Squadrito,Veronica Finisguerra,Sofie Deschoemaeker,Françoise Bruyère,Mathias Wenes,Alexander Hamm,Jens Serneels,Julie Magat,Tapan Bhattacharyya,Tapan Bhattacharyya,Andrey Anisimov,Bénédicte F. Jordan,Kari Alitalo,Patrick H. Maxwell,Bernard Gallez,Zhen W. Zhuang,Yoshihiko Saito,Michael Simons,Michele De Palma,Massimiliano Mazzone +24 more
TL;DR: Unraveling how PHD2 regulates arteriogenesis and artery homeostasis by controlling a specific differentiation state in macrophages is unraveled and new treatment options for ischaemic disorders are suggested.
Journal ArticleDOI
VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis
Anthony A. Lanahan,Karlien Hermans,Filip Claes,Joanna S. Kerley-Hamilton,Zhen W. Zhuang,Frank J. Giordano,Peter Carmeliet,Michael Simons +7 more
TL;DR: It is concluded that activation of the VEGF-mediated arterial morphogenesis cascade requires phosphorylation of the Y(1175) site that is dependent on trafficking of internalized VEGFR2 away from the plasma membrane via a synectin-myosin-VI complex.
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The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis
Anthony A. Lanahan,Xi Zhang,Alessandro Fantin,Zhen W. Zhuang,Felix Rivera-Molina,Katherine R. Speichinger,Claudia Prahst,Jiasheng Zhang,Yingdi Wang,George E. Davis,Derek Toomre,Christiana Ruhrberg,Christiana Ruhrberg,Michael Simons +13 more
TL;DR: It is demonstrated that the N RP1 cytoplasmic domain promotes VEGFR2 trafficking in a PDZ-dependent manner to regulate arteriogenic ERK signaling and establish a role for NRP1 in VEGF-A signaling during vascular morphogenesis.
Journal ArticleDOI
FGF-dependent regulation of VEGF receptor 2 expression in mice.
Masahiro Murakami,Loc T. Nguyen,Kunihiko Hatanaka,William Schachterle,Pei-Yu Chen,Zhen W. Zhuang,Brian L. Black,Michael Simons +7 more
TL;DR: In this paper, the authors investigated VEGF signaling in ECs with disrupted FGF signaling in vitro and in vivo and found that mice with defective FGF signalling exhibited loss of vascular integrity and reduced vascular morphogenesis.