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Robert Schierwagen
Researcher at Goethe University Frankfurt
Publications - 122
Citations - 3165
Robert Schierwagen is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Cirrhosis & Portal hypertension. The author has an hindex of 25, co-authored 102 publications receiving 2040 citations. Previous affiliations of Robert Schierwagen include University of Southern Denmark & University Hospital Bonn.
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Journal ArticleDOI
The PREDICT study uncovers three clinical courses of acutely decompensated cirrhosis that have distinct pathophysiology.
Jonel Trebicka,Javier J.M. Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Martin Janicko,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,William Bernal,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Flemming Bendtsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Osman Ozdogan,Sven Francque,Stephen D. Ryder,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,Debbie L. Shawcross,Ferran Aguilar,Joan Clària,Paola Ponzo,Christian Jansen,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Victor Vargas,Sara Montagnese,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Rajiv Jalan,Richard Moreau,Paolo Angeli,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Michael Praktiknjo,Robert Schierwagen,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Peter Jarcuska,Alexander L. Gerbes,Mattias Mandorfer,Christoph Welsch,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Karen Vagner Danielsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Jörg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Peter Lykke Eriksen,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Daniel Markwardt,Harald Rupprechter,Cornelius Engelmann +126 more
TL;DR: Acute decompensation without ACLF is a heterogeneous condition with three different clinical courses and two major pathophysiological mechanisms: systemic inflammation and portal hypertension.
Journal ArticleDOI
FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis
Len Verbeke,Inge Mannaerts,Robert Schierwagen,Olivier Govaere,Sabine Klein,Ingrid Vander Elst,Petra Windmolders,Ricard Farré,Mathias Wenes,Massimiliano Mazzone,Frederik Nevens,Leo A. van Grunsven,Jonel Trebicka,Wim Laleman +13 more
TL;DR: Preventative and therapeutic effects of FXR agonist obeticholic acid (OCA) inhibits hepatic inflammation in toxic cirrhotic rats resulting in decreased HSC activation and fibrosis.
Journal ArticleDOI
Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis
Robert Schierwagen,Lara Maybüchen,Sebastian Zimmer,Kanishka Hittatiya,Christer Matthias Bäck,Sabine Klein,Frank Erhard Uschner,Winfried Reul,Peter Boor,Georg Nickenig,Christian P. Strassburg,Christian Trautwein,Jogchum Plat,Dieter Lütjohann,Tilman Sauerbruch,Frank Tacke,Jonel Trebicka +16 more
TL;DR: A murine NASH model with distinct hepatic steatosis, inflammation and fibrosis, without renal pathology is described, which is well suitable for NASH research.
Journal ArticleDOI
PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis
Jonel Trebicka,Javier Romaní Fernández,Mária Papp,Paolo Caraceni,Wim Laleman,Carmine Gambino,Ilaria Giovo,Frank Erhard Uschner,Christian Jansen,Cesar Jimenez,Rajeshwar P. Mookerjee,Thierry Gustot,Agustín Albillos,Rafael Bañares,Peter Jarcuska,Christian J. Steib,Thomas Reiberger,Juan Acevedo,Pietro Gatti,Debbie L. Shawcross,Stefan Zeuzem,Alexander Zipprich,Salvatore Piano,Thomas Berg,Tony Bruns,Karen Vagner Danielsen,Minneke J. Coenraad,Manuela Merli,Rudolf E. Stauber,Heinz Zoller,Jose Presa Ramos,Cristina Solé,Germán Soriano,Andrea De Gottardi,Henning Grønbæk,Faouzi Saliba,Christian Trautwein,Haluk Tarik Kani,Sven Francque,Stephen D. Ryder,Pierre Nahon,Pierre Nahon,Manuel Romero-Gómez,Hans Van Vlierberghe,Claire Francoz,Michael Manns,Elisabet Garcia-Lopez,Manuel Tufoni,Alex Amoros,Marco Pavesi,Cristina Sanchez,Michael Praktiknjo,Anna Curto,Carla Pitarch,Antonella Putignano,Esau Moreno,William Bernal,Ferran Aguilar,Joan Clària,Paola Ponzo,Zsuzsanna Vitális,Giacomo Zaccherini,Boglarka Balogh,Alexander L. Gerbes,Victor Vargas,Carlo Alessandria,Mauro Bernardi,Pere Ginès,Richard Moreau,Paolo Angeli,Rajiv Jalan,Vicente Arroyo,Miriam Maschmeier,David Semela,Laure Elkrief,Ahmed Elsharkawy,Tamas Tornai,István Tornai,István Altorjay,Agnese Antognoli,Maurizio Baldassarre,Martina Gagliardi,Eleonora Bertoli,Sara Mareso,Alessandra Brocca,Daniela Campion,Giorgio Maria Saracco,Martina Rizzo,Jennifer Lehmann,Alessandra Pohlmann,Maximilian J. Brol,Johannes Chang,Robert Schierwagen,Elsa Solà,Nesrine Amari,Miguel Á. Rodríguez,Frederik Nevens,Ana Clemente,Martin Janicko,Daniel Markwardt,Mattias Mandorfer,Christoph Welsch,T.M. Welzel,Emanuela Ciraci,Vish Patel,Cristina Ripoll,Adam Herber,Paul Horn,Flemming Bendtsen,Lise Lotte Gluud,Jelte J Schaapman,Oliviero Riggio,Florian Rainer,Joerg Tobiasch Moritz,Monica Mesquita,Edilmar Alvarado-Tapias,Osagie Akpata,Luise Aamann,Didier Samuel,Sylvie Tresson,Pavel Strnad,Roland Amathieu,Roland Amathieu,Macarena Simón-Talero,Francois Smits,Natalie Van den Ende,Javier Martínez,Rita Garcia,Harald Rupprechter,Cornelius Engelmann,Osman Ozdogan +130 more
TL;DR: This study identified precipitants that are significantly associated with a distinct clinical course and prognosis of patients with AD and specific preventive and therapeutic strategies targeting these events may improve outcome in decompensated cirrhosis.
Journal ArticleDOI
Circulating microbiome in blood of different circulatory compartments.
Robert Schierwagen,Camila Alvarez-Silva,Mette Simone Aae Madsen,Carl Christian Kolbe,Carsten Meyer,Daniel Thomas,Frank Erhard Uschner,Fernando Magdaleno,Christian Jansen,Alessandra Pohlmann,Michael Praktiknjo,Gunnar T.R. Hischebeth,Ernst Molitor,Eicke Latz,Eicke Latz,Eicke Latz,Benjamin Lelouvier,Jonel Trebicka,Manimozhiyan Arumugam +18 more
TL;DR: The circulating microbiome in portal vein is characterised as the link between gut and liver and 65 genera belonging to four phyla (predominantly Proteobacteria) in this cohort are identified.