M
Matteo Benelli
Researcher at University of Trento
Publications - 103
Citations - 5585
Matteo Benelli is an academic researcher from University of Trento. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 27, co-authored 86 publications receiving 3784 citations. Previous affiliations of Matteo Benelli include University of Florence & University of Palermo.
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Journal ArticleDOI
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
Himisha Beltran,Himisha Beltran,Davide Prandi,Juan Miguel Mosquera,Juan Miguel Mosquera,Matteo Benelli,Loredana Puca,Joanna Cyrta,Clarisse Marotz,Eugenia G. Giannopoulou,Balabhadrapatruni V. S. K. Chakravarthi,Sooryanarayana Varambally,Scott A. Tomlins,David M. Nanus,Scott T. Tagawa,Eliezer M. Van Allen,Eliezer M. Van Allen,Olivier Elemento,Olivier Elemento,Andrea Sboner,Andrea Sboner,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Mark A. Rubin,Mark A. Rubin,Francesca Demichelis,Francesca Demichelis,Francesca Demichelis +28 more
TL;DR: Analysis of whole-exome sequencing data of metastatic biopsies from patients observed substantial genomic overlap between castration-resistant tumors that were histologically characterized as prostate adenocarcinomas and neuroendocrine prostate cancer (CRPC-NE), supporting the emergence of an alternative, 'AR-indifferent' cell state through divergent clonal evolution as a mechanism of treatment resistance in advanced prostate cancer.
Journal ArticleDOI
Genomic correlates of clinical outcome in advanced prostate cancer.
Wassim Abida,Joanna Cyrta,Joanna Cyrta,Glenn Heller,Davide Prandi,Joshua Armenia,Ilsa Coleman,Marcin Cieslik,Matteo Benelli,Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Andrea Sboner,Tarcisio Fedrizzi,Juan Miguel Mosquera,Brian D. Robinson,Navonil De Sarkar,Lakshmi P. Kunju,Scott A. Tomlins,Yi-Mi Wu,Daniel Nava Rodrigues,Massimo Loda,Massimo Loda,Anuradha Gopalan,Victor E. Reuter,Colin C. Pritchard,Joaquin Mateo,Diletta Bianchini,Susana Miranda,Suzanne Carreira,Pasquale Rescigno,Julie Filipenko,Jacob Vinson,Robert B. Montgomery,Himisha Beltran,Himisha Beltran,Elisabeth I. Heath,Howard I. Scher,Philip W. Kantoff,Mary-Ellen Taplin,Nikolaus Schultz,J. De-Bono,Francesca Demichelis,Peter S. Nelson,Mark A. Rubin,Mark A. Rubin,Arul M. Chinnaiyan,Charles L. Sawyers +47 more
TL;DR: This large analysis integrating mCRPC genomics with histology and clinical outcomes identifies RB1 genomic alteration as a potent predictor of poor outcome, and is a community resource for further interrogation of clinical and molecular associations.
Journal ArticleDOI
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53-and RB1-deficient prostate cancer
Ping Mu,Zeda Zhang,Matteo Benelli,Wouter R. Karthaus,Elizabeth Hoover,Chi-Chao Chen,Chi-Chao Chen,John Wongvipat,Sheng-Yu Ku,Dong Gao,Zhen Cao,Zhen Cao,Neel Shah,Elizabeth J. Adams,Wassim Abida,Philip A. Watson,Davide Prandi,Chun-Hao Huang,Chun-Hao Huang,Elisa de Stanchina,Scott W. Lowe,Scott W. Lowe,Scott W. Lowe,Leigh Ellis,Himisha Beltran,Himisha Beltran,Mark A. Rubin,Mark A. Rubin,David W. Goodrich,Francesca Demichelis,Francesca Demichelis,Charles L. Sawyers,Charles L. Sawyers +32 more
TL;DR: In vitro and in vivo human prostate cancer models are used to show that these tumors can develop resistance to the antiandrogen drug enzalutamide by a phenotypic shift from androgen receptor–dependent luminal epithelial cells to AR-independent basal-like cells.
Journal ArticleDOI
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
Etienne Dardenne,Himisha Beltran,Matteo Benelli,Kaitlyn Gayvert,Adeline Berger,Loredana Puca,Joanna Cyrta,Andrea Sboner,Zohal Noorzad,Theresa Y. MacDonald,Cynthia Cheung,Ka Shing Yuen,Dong Gao,Yu Chen,Martin Eilers,Juan Miguel Mosquera,Juan Miguel Mosquera,Brian D. Robinson,Brian D. Robinson,Olivier Elemento,Mark A. Rubin,Francesca Demichelis,David S. Rickman,David S. Rickman +23 more
TL;DR: In this article, a genetically engineered mouse model and human prostate cancer transcriptome data were integrated to show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC.
Journal ArticleDOI
Patient derived organoids to model rare prostate cancer phenotypes
Loredana Puca,Loredana Puca,Rohan Bareja,Rohan Bareja,Davide Prandi,Reid Shaw,Matteo Benelli,Wouter R. Karthaus,Judy Hess,Michael Sigouros,Adam J. Donoghue,Myriam Kossai,Dong Gao,Joanna Cyrta,Verena Sailer,Aram Vosoughi,Chantal Pauli,Yelena Churakova,Cynthia Cheung,Lesa D. Deonarine,Terra J. McNary,Rachele Rosati,Scott T. Tagawa,David M. Nanus,Juan Miguel Mosquera,Juan Miguel Mosquera,Charles L. Sawyers,Yu Chen,Giorgio Inghirami,Rema Rao,Carla Grandori,Olivier Elemento,Olivier Elemento,Andrea Sboner,Andrea Sboner,Francesca Demichelis,Francesca Demichelis,Mark A. Rubin,Mark A. Rubin,Himisha Beltran,Himisha Beltran +40 more
TL;DR: The generation and characterization of tumor organoids derived from needle biopsies of metastatic lesions from four patients are reported, and genomic, transcriptomic, and epigenomic concordance between organoids and their corresponding patient tumors are demonstrated.