E
Eugenia G. Giannopoulou
Researcher at Hospital for Special Surgery
Publications - 52
Citations - 5539
Eugenia G. Giannopoulou is an academic researcher from Hospital for Special Surgery. The author has contributed to research in topics: Transcription factor & Chromatin. The author has an hindex of 27, co-authored 50 publications receiving 4505 citations. Previous affiliations of Eugenia G. Giannopoulou include Cornell University & City University of New York.
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Journal ArticleDOI
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
Himisha Beltran,Himisha Beltran,Davide Prandi,Juan Miguel Mosquera,Juan Miguel Mosquera,Matteo Benelli,Loredana Puca,Joanna Cyrta,Clarisse Marotz,Eugenia G. Giannopoulou,Balabhadrapatruni V. S. K. Chakravarthi,Sooryanarayana Varambally,Scott A. Tomlins,David M. Nanus,Scott T. Tagawa,Eliezer M. Van Allen,Eliezer M. Van Allen,Olivier Elemento,Olivier Elemento,Andrea Sboner,Andrea Sboner,Levi A. Garraway,Levi A. Garraway,Levi A. Garraway,Mark A. Rubin,Mark A. Rubin,Francesca Demichelis,Francesca Demichelis,Francesca Demichelis +28 more
TL;DR: Analysis of whole-exome sequencing data of metastatic biopsies from patients observed substantial genomic overlap between castration-resistant tumors that were histologically characterized as prostate adenocarcinomas and neuroendocrine prostate cancer (CRPC-NE), supporting the emergence of an alternative, 'AR-indifferent' cell state through divergent clonal evolution as a mechanism of treatment resistance in advanced prostate cancer.
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Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
Jihye Yun,Edouard Mullarky,Edouard Mullarky,Changyuan Lu,Kaitlyn Bosch,Adam Kavalier,Keith Rivera,Jatin Roper,Iok In Christine Chio,Eugenia G. Giannopoulou,Carlo Rago,Ashlesha Muley,John M. Asara,Jihye Paik,Olivier Elemento,Zhengming Chen,Darryl J. Pappin,Lukas E. Dow,Nickolas Papadopoulos,Steven S. Gross,Lewis C. Cantley +20 more
TL;DR: It is found that cultured human CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C, due to increased uptake of the oxidized form of Vitamin C, dehydroascorbate (DHA), via the GLUT1 glucose transporter.
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The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
Dimple Chakravarty,Andrea Sboner,Sujit S. Nair,Eugenia G. Giannopoulou,Ruohan Li,Sven Hennig,Juan Miguel Mosquera,Jonathan Pauwels,Kyung Park,Myriam Kossai,Theresa Y. MacDonald,Jacqueline Fontugne,Nicholas Erho,Ismael A. Vergara,Mercedeh Ghadessi,Elai Davicioni,Robert B. Jenkins,Nallasivam Palanisamy,Zhengming Chen,Shinichi Nakagawa,Tetsuro Hirose,Neil H. Bander,Himisha Beltran,Archa H. Fox,Olivier Elemento,Mark A. Rubin +25 more
TL;DR: Nuclear enriched abundant transcript 1 (NEAT1) is identified as the most significantly overexpressed lncRNA in prostate cancer and evidence that NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription is provided.
Journal ArticleDOI
Ontology visualization methods—a survey
Akrivi Katifori,Constantin Halatsis,George Lepouras,Costas Vassilakis,Eugenia G. Giannopoulou +4 more
TL;DR: The purpose of this article is to present these techniques and categorize their characteristics and features in order to assist method selection and promote future research in the area of ontology visualization.
Journal ArticleDOI
Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling
Yu Qiao,Eugenia G. Giannopoulou,Chun Hin Chan,Sung Ho Park,Shiaoching Gong,Janice Chen,Xiaoyu Hu,Xiaoyu Hu,Olivier Elemento,Lionel B. Ivashkiv,Lionel B. Ivashkiv +10 more
TL;DR: This work found that IFN-γ induced sustained occupancy of transcription factors STAT1, IRF-1, and associated histone acetylation at promoters and enhancers at the TNF, IL6, and IL12B loci and provided a synergy mechanism whereby IFN -γ creates a primed chromatin environment to augment TLR-induced gene transcription.