M
Matthew J. Seasock
Researcher at University of Pennsylvania
Publications - 7
Citations - 369
Matthew J. Seasock is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Genome-wide association study. The author has an hindex of 4, co-authored 7 publications receiving 162 citations. Previous affiliations of Matthew J. Seasock include Temple University.
Papers
More filters
Journal ArticleDOI
Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease
Chengxiang Qiu,Shizheng Huang,Jihwan Park,YoSon Park,Yi-An Ko,Matthew J. Seasock,Joshua S. Bryer,Xiang Xi Xu,Wen-Chao Song,Matthew Palmer,Jon Hill,Paolo Guarnieri,Julie Hawkins,Carine M. Boustany-Kari,Steven S. Pullen,Christopher D. Brown,Katalin Susztak +16 more
TL;DR: Kidney compartment–specific eQTL analysis goes beyond GWAS to reveal causal genes and pathways involved in renal disease development, and reduces Dab2 expression in renal tubules protected mice from CKD.
Journal ArticleDOI
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.
Xin Sheng,Yuting Guan,Ziyuan Ma,Junnan Wu,Hongbo Liu,Chengxiang Qiu,Steven Vitale,Zhen Miao,Matthew J. Seasock,Matthew Palmer,Myung K. Shin,Kevin L. Duffin,Steven S. Pullen,Todd L. Edwards,Jacklyn N. Hellwege,Adriana M. Hung,Mingyao Li,Benjamin F. Voight,Thomas M. Coffman,Christopher D. Brown,Katalin Susztak +20 more
TL;DR: In this paper, the authors generated comprehensive maps of expression quantitative trait loci (eQTLs) for 659 microdissected human kidney samples and identified cell-type eQTL by mapping interactions between cell type abundances and genotypes.
Journal ArticleDOI
Functional methylome analysis of human diabetic kidney disease.
Jihwan Park,Yuting Guan,Xin Sheng,Caroline Gluck,Matthew J. Seasock,A. Ari Hakimi,Chengxiang Qiu,James Pullman,Amit Verma,Hongzhe Li,Matthew Palmer,Katalin Susztak +11 more
TL;DR: The results indicate widespread methylation differences in DKD kidneys and highlights epigenetic changes in the TNF locus and its contribution to the development of nephropathy in patients with diabetes mellitus.
Journal ArticleDOI
The key role of NLRP3 and STING in APOL1-associated podocytopathy
Junnan Wu,Archana Raman,Nathan J Coffey,Xin Sheng,Joseph Wahba,Matthew J. Seasock,Ziyuan Ma,Pazit Beckerman,Dorottya Laczkó,Matthew Palmer,Jeffrey B. Kopp,Jay J. Kuo,Steven S. Pullen,Carine M. Boustany-Kari,Andreas Linkermann,Katalin Susztak +15 more
TL;DR: In this article, the authors reported that expression of G2 APOL1 in the podocytes of Nphs1rtTA/TRE-G2APOL1 mice leads to early activation of the cytosolic nucleotide sensor, stimulator of interferon genes (STING), and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome.
Posted ContentDOI
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments
Xin Sheng,Ziyuan Ma,Junnan Wu,Hongbo Liu,Chengxiang Qiu,Zhen Miao,Matthew J. Seasock,Matthew Palmer,Myung K. Shin,Kevin L. Duffin,Steven S. Pullen,Todd L. Edwards,Jacklyn N. Hellwege,Adriana M. Hung,Mingyao Li,Benjamin F. Voight,Thomas M. Coffman,Christopher D. Brown,Katalin Susztak +18 more
TL;DR: The mechanism of the most commonly used antihypertensive and renal protective drugs is clarified and drug repurposing opportunities for kidney disease are identified and identified by mapping interactions between cell type abundance and genotype.