M
Matthew Palmer
Researcher at University of Pennsylvania
Publications - 59
Citations - 2293
Matthew Palmer is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 21, co-authored 55 publications receiving 1374 citations. Previous affiliations of Matthew Palmer include Emory University & Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis
Ki Wung Chung,Poonam Dhillon,Shizheng Huang,Xin Sheng,Rojesh Shrestha,Chengxiang Qiu,Brett A. Kaufman,Jihwan Park,Liming Pei,Liming Pei,Joseph A. Baur,Matthew Palmer,Katalin Susztak +12 more
TL;DR: Ablation of STING ameliorated kidney fibrosis in mouse models of chronic kidney disease, demonstrating how TFAM sequesters mtDNA to limit the inflammation leading to fibrosis.
Journal ArticleDOI
Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice
Pazit Beckerman,Jing Bi-Karchin,Ae Seo Deok Park,Chengxiang Qiu,Patrick D. Dummer,Irfana Soomro,Carine M. Boustany-Kari,Steven S. Pullen,Jeffrey H. Miner,Chien-An Andy Hu,Tibor Rohacs,Kazunori Inoue,Shuta Ishibe,Moin A. Saleem,Matthew Palmer,Ana Maria Cuervo,Jeffrey B. Kopp,Katalin Susztak +17 more
TL;DR: It is found that expression of the risk-variant APOL1 alleles interferes with endosomal trafficking and blocks autophagic flux, which ultimately leads to inflammatory-mediated podocyte death and glomerular scarring.
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Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease
Chengxiang Qiu,Shizheng Huang,Jihwan Park,YoSon Park,Yi-An Ko,Matthew J. Seasock,Joshua S. Bryer,Xiang Xi Xu,Wen-Chao Song,Matthew Palmer,Jon Hill,Paolo Guarnieri,Julie Hawkins,Carine M. Boustany-Kari,Steven S. Pullen,Christopher D. Brown,Katalin Susztak +16 more
TL;DR: Kidney compartment–specific eQTL analysis goes beyond GWAS to reveal causal genes and pathways involved in renal disease development, and reduces Dab2 expression in renal tubules protected mice from CKD.
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Fossil leaf economics quantified: calibration, Eocene case study, and implications
Dana L. Royer,Lawren Sack,Peter Wilf,Christopher H. Lusk,Gregory J. Jordan,Ülo Niinemets,Ian J. Wright,Mark Westoby,Bárbara Cariglino,Phyllis D. Coley,Asher D. Cutter,Asher D. Cutter,Kirk R. Johnson,Conrad C. Labandeira,Angela T. Moles,Angela T. Moles,Matthew Palmer,Fernando Valladares +17 more
TL;DR: Reconstructed MA in the fossil species is negatively correlated with levels of insect herbivory, whether measured as the proportion of leaves with insect damage, theportion of leaf area removed by herbivores, or the diversity of insect-damage morphotypes, and these correlations reflect fundamental trade-offs in plant-herbivore associations.
Journal ArticleDOI
Proteasome inhibitor associated thrombotic microangiopathy.
Jennifer C. Yui,Jan Van Keer,Brendan M. Weiss,Adam Waxman,Matthew Palmer,Vivette D. D'Agati,Efstathios Kastritis,Meletios A. Dimopoulos,Ravi Vij,Dhruv Bansal,David Dingli,Samih H. Nasr,Nelson Leung +12 more
TL;DR: Eleven patients from six medical centers from around the world who developed TMA while being treated with proteasome inhibitors are described to better characterize the role of PI in the etiology of drug‐induced TMA.