A
Adriana M. Hung
Researcher at Vanderbilt University Medical Center
Publications - 168
Citations - 6052
Adriana M. Hung is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Kidney disease. The author has an hindex of 34, co-authored 123 publications receiving 3763 citations. Previous affiliations of Adriana M. Hung include Vanderbilt University & University of California, San Francisco.
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Journal ArticleDOI
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Evangelos Evangelou,Evangelos Evangelou,Helen R. Warren,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsud,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrera,Claudia P. Cabrera,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,Kelly Cho,J. Michael Gaziano,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Nabi Shah,Praveen Surendran,Sébastien Thériault,Sébastien Thériault,Niek Verweij,Niek Verweij,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Dorret I. Boomsma,Erwin P. Bottinger,Peter S. Braund,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola Del Greco M,Cumhur Y Demirkale,Marcus Dörr,Georg Ehret,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Anuj Goel,Alan J. Gow,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Erik Ingelsson,Alan James,Alan James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan,Bernard Keavney,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Ruth J. F. Loos,Lorna M. Lopez,Lorna M. Lopez,Lorna M. Lopez,Yingchang Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Christopher P. Nelson,Teemu J. Niiranen,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Aarno Palotie,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Jerome I. Rotter,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Nilesh J. Samani,Antti-Pekka Sarin,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Völker,Peter Vollenweider,Dragana Vuckovic,Dragana Vuckovic,Hugh Watkins,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,Weihua Zhang,John Attia,Adam S. Butterworth,Adam S. Butterworth,Daniel I. Chasman,Daniel I. Chasman,David Conen,David Conen,Francesco Cucca,Francesco Cucca,John Danesh,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Christopher Newton-Cheh,Morris J. Brown,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Bruce M. Psaty,Ioanna Tzoulaki,Ioanna Tzoulaki,Michael R. Barnes,Michael R. Barnes,Louise V. Wain,Louise V. Wain,Paul Elliott,Mark J. Caulfield,Mark J. Caulfield +341 more
TL;DR: In this article, the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry was conducted.
Journal ArticleDOI
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Ayush Giri,Jacklyn N. Hellwege,Jacob M. Keaton,Jacob M. Keaton,Jihwan Park,Chengxiang Qiu,Helen R. Warren,Helen R. Warren,Eric S. Torstenson,Eric S. Torstenson,Csaba P. Kovesdy,Yan V. Sun,Otis D. Wilson,Otis D. Wilson,Cassianne Robinson-Cohen,Christianne L. Roumie,Cecilia P. Chung,K A Birdwell,K A Birdwell,Scott M. Damrauer,Scott L. DuVall,Derek Klarin,Kelly Cho,Yu Wang,Evangelos Evangelou,Evangelos Evangelou,Claudia P. Cabrera,Claudia P. Cabrera,Louise V. Wain,Louise V. Wain,Rojesh Shrestha,Brian S. Mautz,Elvis A. Akwo,Muralidharan Sargurupremraj,Stéphanie Debette,Michael Boehnke,Laura J. Scott,Jian'an Luan,Zhao J-H.,Sara M. Willems,Sébastien Thériault,Nabi Shah,Nabi Shah,Christopher Oldmeadow,Peter Almgren,Ruifang Li-Gao,Niek Verweij,Thibaud Boutin,Massimo Mangino,Massimo Mangino,Ioanna Ntalla,Elena V. Feofanova,Praveen Surendran,James P. Cook,Savita Karthikeyan,Najim Lahrouchi,Ching-Ti Liu,Nuno Sepúlveda,Tom G. Richardson,Aldi T. Kraja,Philippe Amouyel,Martin Farrall,Neil Poulter,Markku Laakso,Eleftheria Zeggini,Peter S. Sever,Robert A. Scott,Claudia Langenberg,Nicholas J. Wareham,David Conen,Palmer Cna.,John Attia,Daniel I. Chasman,Paul M. Ridker,Olle Melander,Dennis O. Mook-Kanamori,Harst Pvd.,Francesco Cucca,David Schlessinger,Caroline Hayward,Tim D. Spector,Jarvelin M-R.,Branwen J. Hennig,Branwen J. Hennig,Nicholas J. Timpson,Wei W-Q.,J C Smith,Yaomin Xu,Michael E. Matheny,E E Siew,C M Lindgren,C M Lindgren,C M Lindgren,Herzig K-H.,George Dedoussis,Josh C. Denny,Bruce M. Psaty,Howson Jmm.,Patricia B. Munroe,Patricia B. Munroe,Christopher Newton-Cheh,Mark J. Caulfield,Mark J. Caulfield,Paul Elliott,Paul Elliott,J M Gaziano,J M Gaziano,John Concato,Wilson Pwf.,Philip S. Tsao,D.R. Velez Edwards,D.R. Velez Edwards,Katalin Susztak,Christopher J. O'Donnell,Adriana M. Hung,Adriana M. Hung,Todd L. Edwards,Todd L. Edwards +117 more
TL;DR: Analysis of blood pressure data from the Million Veteran Program trans-ethnic cohort identifies common and rare variants, and genetically predicted gene expression across multiple tissues associated with systolic, diastolic and pulse pressure in over 775,000 individuals.
Journal ArticleDOI
Comparative Effectiveness of Sulfonylurea and Metformin Monotherapy on Cardiovascular Events in Type 2 Diabetes Mellitus: A Cohort Study
Christianne L. Roumie,Adriana M. Hung,Robert A. Greevy,Carlos G. Grijalva,Xulei Liu,Harvey J. Murff,Tom A. Elasy,Marie R. Griffin +7 more
TL;DR: Use of sulfonylureas compared with metformin for initial treatment of diabetes was associated with an increased hazard of CVD events or death.
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Matthias Wuttke,Yong Li,Man Li,Karsten B. Sieber,Mary F. Feitosa,Mathias Gorski,Adrienne Tin,Lihua Wang,Audrey Y. Chu,Anselm Hoppmann,Holger Kirsten,Ayush Giri,Jin-Fang Chai,Gardar Sveinbjornsson,Bamidele O. Tayo,Teresa Nutile,Christian Fuchsberger,Jonathan Marten,Massimiliano Cocca,Sahar Ghasemi,Yizhe Xu,Katrin Horn,Damia Noce,Peter J. van der Most,Sanaz Sedaghat,Zhi Yu,Masato Akiyama,Saima Afaq,Tarunveer S. Ahluwalia,Peter Almgren,Najaf Amin,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Michael Boehnke,Eric Boerwinkle,Mathilde Boissel,Erwin P. Bottinger,Thibaud Boutin,Hermann Brenner,Marco Brumat,Ralph Burkhardt,Adam S. Butterworth,Eric Campana,Archie Campbell,Harry Campbell,Mickaël Canouil,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Miao-Ling Chee,Miao-Li Chee,Xu Chen,Ching-Yu Cheng,Yurong Cheng,Kaare Christensen,Renata Cifkova,Marina Ciullo,Maria Pina Concas,James P. Cook,Josef Coresh,Tanguy Corre,Cinzia Sala,Daniele Cusi,John Danesh,E. Warwick Daw,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Frauke Degenhardt,Graciela E. Delgado,Ayse Demirkan,Emanuele Di Angelantonio,Katalin Dittrich,Jasmin Divers,Rajkumar Dorajoo,Kai-Uwe Eckardt,Georg Ehret,Paul Elliott,Karlhans Endlich,Michele K. Evans,Janine F. Felix,Valencia Hui Xian Foo,Oscar H. Franco,Andre Franke,Barry I. Freedman,Sandra Freitag-Wolf,Yechiel Friedlander,Philippe Froguel,Ron T. Gansevoort,He Gao,Paolo Gasparini,J. Michael Gaziano,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Franco Giulianini,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Catharina A. Hartman,Caroline Hayward,Jacklyn N. Hellwege,Chew-Kiat Heng,Andrew A. Hicks,Edith Hofer,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Olafur S. Indridason,Erik Ingelsson,Marcus Ising,Vincent W. V. Jaddoe,Johanna Jakobsdottir,Jost B. Jonas,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Candace M. Kammerer,Masahiro Kanai,Mika Kastarinen,Shona M. Kerr,Chiea Chuen Khor,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Aldi T. Kraja,Alena Krajčoviechová,Holly Kramer,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Mikko Kuokkanen,Johanna Kuusisto,Martina La Bianca,Markku Laakso,Leslie A. Lange,Carl D. Langefeld,Jeannette Lee,Benjamin Lehne,Terho Lehtimäki,Wolfgang Lieb,Su Chi Lim,Lars Lind,Cecilia M. Lindgren,Jun Liu,Jianjun Liu,Markus Loeffler,Ruth J. F. Loos,Susanne Lucae,Mary Ann Lukas,Leo-Pekka Lyytikäinen,Reedik Mägi,Patrik K. E. Magnusson,Anubha Mahajan,Nicholas G. Martin,Jade Martins,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Olle Melander,Andres Metspalu,Evgenia K. Mikaelsdottir,Yuri Milaneschi,Kozeta Miliku,Pashupati P. Mishra,VA Million Veteran Program,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Josyf C. Mychaleckyj,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Michelle L. O'Donoghue,Isleifur Olafsson,Albertine J. Oldehinkel,Marju Orho-Melander,Willem H. Ouwehand,Sandosh Padmanabhan,Nicholette D. Palmer,Runolfur Palsson,Brenda W.J.H. Penninx,Thomas T. Perls,Markus Perola,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Anna I. Podgornaia,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Peter P. Pramstaller,Michael Preuss,Bram P. Prins,Michael A. Province,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Dermot F. Reilly,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Paul M. Ridker,Fernando Rivadeneira,Federica Rizzi,David J. Roberts,Antonietta Robino,Peter Rossing,Igor Rudan,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Charumathi Sabanayagam,Veikko Salomaa,Erika Salvi,Kai-Uwe Saum,Helena Schmidt,Reinhold Schmidt,Ben Schöttker,Christina-Alexandra Schulz,Nicole Schupf,Christian M. Shaffer,Yuan Shi,Albert V. Smith,Blair H. Smith,Nicole Soranzo,Cassandra N. Spracklen,Konstantin Strauch,Heather M. Stringham,Michael Stumvoll,Per Svensson,Silke Szymczak,E-Shyong Tai,Salman M. Tajuddin,Nicholas Y. Q. Tan,Kent D. Taylor,Andrej Teren,Yih Chung Tham,Joachim Thiery,Chris H. L. Thio,Hauke Thomsen,Gudmar Thorleifsson,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,Ioanna Tzoulaki,André G. Uitterlinden,Simona Vaccargiu,Rob M. van Dam,Pim van der Harst,Cornelia M. van Duijn,Digna R. Velez Edward,Niek Verweij,Suzanne Vogelezang,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,Lars Wallentin,Ya Xing Wang,Chaolong Wang,Dawn M. Waterworth,Wen Bin Wei,Harvey D. White,John Whitfield,Sarah H. Wild,James F. Wilson,Mary K. Wojczynski,Charlene A. Wong,Tien Yin Wong,Liang Xu,Qiong Yang,Masayuki Yasuda,Laura M. Yerges-Armstrong,Weihua Zhang,Alan B. Zonderman,Jerome I. Rotter,Murielle Bochud,Bruce M. Psaty,Veronique Vitart,James G. Wilson,Abbas Dehghan,Afshin Parsa,Daniel I. Chasman,Kevin Ho,Andrew P. Morris,Olivier Devuyst,Shreeram Akilesh,Sarah A. Pendergrass,Xueling Sim,Carsten A. Böger,Yukinori Okada,Todd L. Edwards,Harold Snieder,Kari Stefansson,Adriana M. Hung,Iris M. Heid,Markus Scholz,Alexander Teumer,Anna Köttgen,Cristian Pattaro +327 more
TL;DR: Trans-ancestry meta-analysis of estimated glomerular filtration rate (eGFR) from 1,046,070 individuals identifies 264 associated loci, providing a resource of molecular targets for translational research of chronic kidney disease.
Journal ArticleDOI
Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
Adrienne Tin,Jonathan Marten,Victoria L. Halperin Kuhns,Yong Li,Matthias Wuttke,Holger Kirsten,Karsten B. Sieber,Chengxiang Qiu,Mathias Gorski,Mathias Gorski,Zhi Yu,Ayush Giri,Ayush Giri,Gardar Sveinbjornsson,Man Li,Audrey Y. Chu,Anselm Hoppmann,Luke J. O’Connor,Bram P. Prins,Teresa Nutile,Damia Noce,Masato Akiyama,Massimiliano Cocca,Sahar Ghasemi,Peter J. van der Most,Katrin Horn,Yizhe Xu,Christian Fuchsberger,Sanaz Sedaghat,Saima Afaq,Saima Afaq,Najaf Amin,Johan Ärnlöv,Johan Ärnlöv,Stephan J. L. Bakker,Nisha Bansal,Daniela Baptista,Sven Bergmann,Sven Bergmann,Sven Bergmann,Mary L. Biggs,Ginevra Biino,Eric Boerwinkle,Erwin P. Bottinger,Thibaud Boutin,Marco Brumat,Ralph Burkhardt,Ralph Burkhardt,Eric Campana,Archie Campbell,Harry Campbell,Robert J. Carroll,Eulalia Catamo,John C. Chambers,Marina Ciullo,Maria Pina Concas,Josef Coresh,Tanguy Corre,Tanguy Corre,Daniele Cusi,Sala Cinzia Felicita,Martin H. de Borst,Alessandro De Grandi,Renée de Mutsert,Aiko P. J. de Vries,Graciela E. Delgado,Ayse Demirkan,Ayse Demirkan,Olivier Devuyst,Katalin Dittrich,Kai-Uwe Eckardt,Kai-Uwe Eckardt,Georg Ehret,Karlhans Endlich,Michele K. Evans,Ron T. Gansevoort,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Martin Gögele,Scott D. Gordon,Daniel F. Gudbjartsson,Vilmundur Gudnason,Toomas Haller,Pavel Hamet,Tamara B. Harris,Caroline Hayward,Andrew A. Hicks,Edith Hofer,Hilma Holm,Wei Huang,Nina Hutri-Kähönen,Shih-Jen Hwang,M. Arfan Ikram,Raychel M. Lewis,Erik Ingelsson,Johanna Jakobsdottir,Ingileif Jonsdottir,Helgi Jonsson,Peter K. Joshi,Navya Shilpa Josyula,Bettina Jung,Mika Kähönen,Yoichiro Kamatani,Masahiro Kanai,Shona M. Kerr,Wieland Kiess,Marcus E. Kleber,Wolfgang Koenig,Wolfgang Koenig,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Bernhard K. Krämer,Florian Kronenberg,Michiaki Kubo,Brigitte Kühnel,Martina La Bianca,Leslie A. Lange,Benjamin Lehne,Terho Lehtimäki,Jun Liu,Jun Liu,Markus Loeffler,Ruth J. F. Loos,Leo-Pekka Lyytikäinen,Reedik Mägi,Anubha Mahajan,Anubha Mahajan,Nicholas G. Martin,Winfried März,Winfried März,Winfried März,Deborah Mascalzoni,Koichi Matsuda,Christa Meisinger,Thomas Meitinger,Andres Metspalu,Yuri Milaneschi,Christopher J. O'Donnell,Christopher J. O'Donnell,Otis D. Wilson,J. Michael Gaziano,J. Michael Gaziano,Pashupati P. Mishra,Karen L. Mohlke,Nina Mononen,Grant W. Montgomery,Dennis O. Mook-Kanamori,Martina Müller-Nurasyid,Girish N. Nadkarni,Mike A. Nalls,Matthias Nauck,Kjell Nikus,Boting Ning,Ilja M. Nolte,Raymond Noordam,Jeffrey R. O'Connell,Isleifur Olafsson,Sandosh Padmanabhan,Brenda W.J.H. Penninx,Thomas T. Perls,Annette Peters,Mario Pirastu,Nicola Pirastu,Giorgio Pistis,Ozren Polasek,Belen Ponte,David J. Porteous,Tanja Poulain,Michael Preuss,Ton J. Rabelink,Laura M. Raffield,Olli T. Raitakari,Olli T. Raitakari,Rainer Rettig,Myriam Rheinberger,Kenneth Rice,Federica Rizzi,Antonietta Robino,Igor Rudan,Alena Krajčoviechová,Renata Cifkova,Rico Rueedi,Rico Rueedi,Daniela Ruggiero,Kathleen A. Ryan,Yasaman Saba,Erika Salvi,Helena Schmidt,Reinhold Schmidt,Christian M. Shaffer,Albert V. Smith,Blair H. Smith,Cassandra N. Spracklen,Konstantin Strauch,Michael Stumvoll,Patrick Sulem,Salman M. Tajuddin,Andrej Teren,Joachim Thiery,Chris H. L. Thio,Unnur Thorsteinsdottir,Daniela Toniolo,Anke Tönjes,Johanne Tremblay,André G. Uitterlinden,Simona Vaccargiu,Pim van der Harst,Cornelia M. van Duijn,Cornelia M. van Duijn,Cornelia M. van Duijn,Niek Verweij,Uwe Völker,Peter Vollenweider,Gérard Waeber,Melanie Waldenberger,John Whitfield,Sarah H. Wild,James F. Wilson,Qiong Yang,Weihua Zhang,Weihua Zhang,Alan B. Zonderman,Murielle Bochud,James G. Wilson,Sarah A. Pendergrass,Kevin Ho,Afshin Parsa,Afshin Parsa,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Carsten A. Böger,Harold Snieder,Adam S. Butterworth,Yukinori Okada,Todd L. Edwards,Todd L. Edwards,Kari Stefansson,Katalin Susztak,Markus Scholz,Iris M. Heid,Adriana M. Hung,Adriana M. Hung,Alexander Teumer,Cristian Pattaro,Owen M. Woodward,Veronique Vitart,Anna Köttgen,Anna Köttgen +251 more
TL;DR: A trans-ancestry genome-wide association study of serum urate levels identifies 183 loci that improve the prediction of gout in an independent cohort of 334,880 individuals, and implicates the kidney and liver as key target organs and prioritize potential causal genes.