Matthew L. Kraushar

TL;DR: This work shows that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a developmental stage-dependent manner in mice, and identifies a crucial role for HuR in neocorticals development as a translational gatekeeper for functionally related mRNA subgroups and polysomal protein specificity.

TL;DR: A transcriptome screen of candidate molecules associated with post-transcriptional mRNA processing that are differentially expressed at key developmental time points across neocortical prenatal neurogenesis are presented.

TL;DR: The timed secretion of Wingless-related MMTV (mouse mammary tumor virus) integration site 3 (WNT3) by ingrowing axons from the thalamus regulates the combinatorial composition of ribosomal proteins in developing neocortex, which is termed the “neocortical ribosome signature.”

TL;DR: Translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex is reported and the neurodevelopmental risk of post-transcriptional dysregulation is shown.

TL;DR: It is demonstrated that restoration of one splice isoform of FasII can rescue synaptic morphology in beag mutants while expression of other isoforms cannot, and that this FasII isoform has unique functions in synaptic development independent of transsynaptic adhesion.