M
Matthew Wiggin
Researcher at University of British Columbia
Publications - 26
Citations - 3810
Matthew Wiggin is an academic researcher from University of British Columbia. The author has contributed to research in topics: Nanopore & Magnetic tweezers. The author has an hindex of 12, co-authored 25 publications receiving 3307 citations. Previous affiliations of Matthew Wiggin include Delft University of Technology.
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Journal ArticleDOI
The Potential and Challenges of Nanopore Sequencing
Daniel Branton,David W. Deamer,Andre Marziali,Hagan Bayley,Steven A. Benner,Thomas Z. Butler,Massimiliano Di Ventra,Slaven Garaj,Andrew Hibbs,Xiaohua Huang,Stevan B Jovanovich,Predrag S Krstic,Stuart Lindsay,Xinsheng Sean Ling,Carlos H. Mastrangelo,Amit Meller,John S. Oliver,Yuriy V. Pershin,J. Michael Ramsey,Robert Riehn,Gautam V. Soni,Vincent Tabard-Cossa,Meni Wanunu,Matthew Wiggin,Jeffery A. Schloss +24 more
TL;DR: A nanopore-based device provides single-molecule detection and analytical capabilities that are achieved by electrophoretically driving molecules in solution through a nano-scale pore, a unique analytical capability that makes inexpensive, rapid DNA sequencing a possibility.
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Noise analysis and reduction in solid-state nanopores
TL;DR: In this article, a technique for reducing the dielectric noise by curing polydimethylsiloxane (PDMS) on the nanopore support chip was presented, yielding an unprecedented signal-to-noise ratio when observing dsDNA translocation events and ssDNA probe capture for force spectroscopy applications.
Journal ArticleDOI
LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants
Kathryn Westendorf,Stefanie Zentelis,Lingshu Wang,Denisa Foster,Peter Edward Vaillancourt,Matthew Wiggin,Erica Lovett,R. van der Lee,Jorg Hendle,A. Pustilnik,J. Michael Sauder,Lucas Kraft,Yu Ri Hwang,Robert W. Siegel,Jinbiao Chen,Beverly A. Heinz,Richard E. Higgs,Nicole L. Kallewaard,Kevin R. Jepson,Rodrigo Goya,Maia A. Smith,D. W. Collins,Davide Pellacani,Ping Xiang,Valentine de Puyraimond,Marketa Ricicova,Lindsay DeVorkin,Caitlin Jean Pritchard,Aoise O’Neill,Kush Dalal,Pankaj Panwar,Harveer Singh Dhupar,Fabian A. Garces,Courtney A. Cohen,John M. Dye,Kathleen E Huie,Catherine V. Badger,Darwyn Kobasa,Jonathan Audet,J. J. Freitas,Saleema Hassanali,Ina E. Hughes,Luis Munoz,Holly C. Palma,Bharathi Ramamurthy,Robert W. Cross,Thomas W. Geisbert,Vineet Menacherry,Kumari G. Lokugamage,Viktoriya Borisevich,Iliana Lanz,Lisa Anderson,Payal Sipahimalani,Kizzmekia S. Corbett,Eun Sung Yang,Yi Zhang,Wei Shi,Tongqing Zhou,Misook Choe,John Misasi,Peter D. Kwong,Nancy J. Sullivan,Barney S. Graham,Tara L. Fernandez,Carl L. Hansen,Ester Falconer,John R. Mascola,Bryan Edward Jones,Bryan C. Barnhart +68 more
TL;DR: In this paper , the authors used a high-throughput B cell screening pipeline to identify a highly potent SARS-CoV-2 spike glycoprotein receptor binding domain (RBD)-specific antibody.
Journal ArticleDOI
A Nanosensor for Transmembrane Capture and Identification of Single Nucleic Acid Molecules
TL;DR: The detection method presented in this article is a candidate for in vivo single-molecule detection and, through parallelization in a synthetic device, for genotyping and global transcription profiling from small samples.
Journal ArticleDOI
Freely orbiting magnetic tweezers to directly monitor changes in the twist of nucleic acids
TL;DR: Free orbiting MT (FOMT) is presented that allow the measurement of equilibrium fluctuations and changes in the twist of tethered nucleic acid molecules and to measure the force-dependent torsional stiffness of DNA from equilibrium rotational fluctuations.