M
Matthias Habjan
Researcher at Max Planck Society
Publications - 29
Citations - 3256
Matthias Habjan is an academic researcher from Max Planck Society. The author has contributed to research in topics: Virus & Interferon. The author has an hindex of 21, co-authored 27 publications receiving 2794 citations. Previous affiliations of Matthias Habjan include University of St. Gallen & University Medical Center Freiburg.
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Journal ArticleDOI
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
Roland Züst,Roland Züst,Luisa Cervantes-Barragan,Matthias Habjan,Reinhard Maier,Benjamin W. Neuman,John Ziebuhr,John Ziebuhr,Kristy J. Szretter,Susan C. Baker,Winfried Barchet,Michael S. Diamond,Stuart G. Siddell,Burkhard Ludewig,Burkhard Ludewig,Volker Thiel,Volker Thiel +16 more
TL;DR: It is demonstrated that the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5, which suggests that RNA modifications such as 2-methylation provide a molecular signature for the discrimination of self and non-self mRNA.
Journal ArticleDOI
Processing of genome 5' termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction.
Matthias Habjan,Ida Andersson,Jonas Klingström,Michael Schümann,Arnold Martin,Petra Zimmermann,Valentina Wagner,Andreas Pichlmair,Urs Schneider,Elke Mühlberger,Ali Mirazimi,Friedemann Weber +11 more
TL;DR: RIG-I is established as a major intracellular recognition receptor for the genome of most negative-strand RNA viruses and the cleavage of triphosphates at the RNA 5′ end as a strategy of viruses to evade the innate immune response is defined.
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TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium
Stephanie Bertram,Stephanie Bertram,Ronald Dijkman,Matthias Habjan,Adeline Heurich,Stefanie Gierer,Ilona Glowacka,Kathrin Welsch,Michael Winkler,Heike Schneider,Heike Hofmann-Winkler,Volker Thiel,Volker Thiel,Stefan Pöhlmann,Stefan Pöhlmann +14 more
TL;DR: Results indicate that HCoV-229E can employ redundant proteolytic pathways to ensure its activation in host cells, and suggest that diverse human respiratory viruses are activated by TMPRSS2, which may constitute a target for antiviral intervention.
Journal ArticleDOI
Viral immune modulators perturb the human molecular network by common and unique strategies
Andreas Pichlmair,Kumaran Kandasamy,Gualtiero Alvisi,Orla Mulhern,Roberto Sacco,Matthias Habjan,Marco Binder,Adrijana Stefanovic,Carol-Ann Eberle,Adriana Goncalves,Tilmann Bürckstümmer,André C. Müller,Astrid Fauster,Cathleen Holze,Kristina Lindsten,Stephen Goodbourn,Georg Kochs,Friedemann Weber,Friedemann Weber,Ralf Bartenschlager,Andrew G. Bowie,Keiryn L. Bennett,Jacques Colinge,Giulio Superti-Furga +23 more
TL;DR: It is shown that different viral perturbation patterns of the host molecular defence network can be deduced from a mass-spectrometry-based host-factor survey in a defined human cellular system by using 70 innate immune-modulating viORFs from 30 viral species.
Journal ArticleDOI
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.
Matthias Habjan,Andreas Pichlmair,Andreas Pichlmair,Richard M. Elliott,Anna K. Överby,Timo Glatter,Matthias Gstaiger,Giulio Superti-Furga,Hermann Unger,Friedemann Weber +9 more
TL;DR: It is demonstrated here in vitro and in vivo that a substantial part of the antiviral activity of IFN against RVFV is due to a double-stranded RNA-dependent protein kinase (PKR), which may explain the extraordinary pathogenicity of this virus.