K
Kristy J. Szretter
Researcher at Washington University in St. Louis
Publications - 25
Citations - 5395
Kristy J. Szretter is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 24, co-authored 25 publications receiving 4849 citations. Previous affiliations of Kristy J. Szretter include National Center for Immunization and Respiratory Diseases & Centers for Disease Control and Prevention.
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Journal ArticleDOI
IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
Yaming Wang,Kristy J. Szretter,William Vermi,William Vermi,Susan Gilfillan,Cristina Rossini,Marina Cella,Alexander D. Barrow,Alexander D. Barrow,Michael S. Diamond,Marco Colonna +10 more
TL;DR: It is found that keratinocytes and neurons were the main sources of IL-34, which specifically directs the differentiation of myeloid cells in the skin epidermis and CNS.
Journal ArticleDOI
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
Stephane Daffis,Kristy J. Szretter,Jill Schriewer,Jianqing Li,Soonjeon Youn,John S. Errett,Tsai-Yu Lin,Stewart W. Schneller,Roland Züst,Hongping Dong,Volker Thiel,Volker Thiel,Ganes C. Sen,Volker Fensterl,William B. Klimstra,Theodore C. Pierson,R. Mark L. Buller,Michael Gale,Pei Yong Shi,Michael S. Diamond +19 more
TL;DR: It is demonstrated that a West Nile virus mutant that lacks 2′-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling, and suggested an evolutionary explanation for 2-O methylation of cellular mRNA: to distinguish self from non-self RNA.
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Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
Roland Züst,Roland Züst,Luisa Cervantes-Barragan,Matthias Habjan,Reinhard Maier,Benjamin W. Neuman,John Ziebuhr,John Ziebuhr,Kristy J. Szretter,Susan C. Baker,Winfried Barchet,Michael S. Diamond,Stuart G. Siddell,Burkhard Ludewig,Burkhard Ludewig,Volker Thiel,Volker Thiel +16 more
TL;DR: It is demonstrated that the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5, which suggests that RNA modifications such as 2-methylation provide a molecular signature for the discrimination of self and non-self mRNA.
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Avian Influenza (H5N1) Viruses Isolated from Humans in Asia in 2004 Exhibit Increased Virulence in Mammals
Taronna R. Maines,Xui Hua Lu,Steven M. Erb,Lindsay Edwards,Jeannette Guarner,Patricia W. Greer,Doan C. Nguyen,Kristy J. Szretter,Li-Mei Chen,Pranee Thawatsupha,Malinee Chittaganpitch,Sunthareeya Waicharoen,Diep T. Nguyen,Tung Nguyen,Hanh T. Nguyen,Jae Hong Kim,Long T. Hoang,Chun Kang,Lien S. Phuong,Wilina Lim,Sherif R. Zaki,Ruben O. Donis,Nancy J. Cox,Jacqueline M. Katz,Terrence M. Tumpey +24 more
TL;DR: The results demonstrate the general equivalence of mouse and ferret models for assessment of the virulence of 2003 and 2004 H5N1 viruses, however, the apparent enhancement ofvirulence of these viruses in humans in 2004 was better reflected in the ferret.
Journal ArticleDOI
Role of Host Cytokine Responses in the Pathogenesis of Avian H5N1 Influenza Viruses in Mice
Kristy J. Szretter,Shivaprakash Gangappa,Xuihua Lu,Chalanda Smith,Wun-Ju Shieh,Sherif R. Zaki,Suryaprakash Sambhara,Terrence M. Tumpey,Jacqueline M. Katz +8 more
TL;DR: The results suggest that TNF-α may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H 5N1 disease.