Matthias Schmitt

TL;DR: DynEq-CMR–derived ECV shows a good correlation with histological collagen volume fraction throughout the whole heart, and varied significantly according to contrast dose, myocardial region, and sex.

TL;DR: Across a wide spectrum of patients with DCM, LGE is strongly and independently associated with ventricular arrhythmia or SCD, which raises 2 major questions to be addressed in future studies: whether patients with LGE could benefit from primary prevention I CDs irrespective of their left ventricular ejection fractions, while patients without LGE might not need preventive ICDs despite having severeleft ventricular dysfunction.

TL;DR: MF measured by ECV is associated with hospitalization for heart failure, death, or both and may represent a principal phenotype of cardiac vulnerability that improves risk stratification.

TL;DR: It is demonstrated, for the first time, that endogenous ET-1 production directly regulates large artery PWV in vivo, and drugs that block ET(A) receptors may be effective in reducing large artery stiffness in humans, and thus cardiovascular risk.

TL;DR: The data indicate that under resting conditions, local NO production modulates human iliac artery distensibility and that exogenous NO increases arterialdistensibility.