M
Matthijs Raaben
Researcher at Netherlands Cancer Institute
Publications - 34
Citations - 3439
Matthijs Raaben is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Coronavirus & Viral replication. The author has an hindex of 20, co-authored 34 publications receiving 2870 citations. Previous affiliations of Matthijs Raaben include Utrecht University & Harvard University.
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Journal ArticleDOI
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
Jan E. Carette,Jan E. Carette,Matthijs Raaben,Anthony C. Wong,Andrew S. Herbert,Gregor Obernosterer,Gregor Obernosterer,Nirupama Mulherkar,Ana I. Kuehne,Philip J. Kranzusch,April M. Griffin,Gordon Ruthel,Paola Dal Cin,John M. Dye,Sean P. J. Whelan,Kartik Chandran,Thijn R. Brummelkamp,Thijn R. Brummelkamp +17 more
TL;DR: It is shown that membrane fusion mediated by filovirus glycoproteins and viral escape from the vesicular compartment require the NPC1 protein, independent of its known function in cholesterol transport, which indicates potential antiviral strategies to combat these deadly agents.
Journal ArticleDOI
Ebola virus entry requires the host-programmed recognition of an intracellular receptor
Emily Happy Miller,Gregor Obernosterer,Matthijs Raaben,Andrew S. Herbert,Maika S. Deffieu,Anuja Krishnan,Esther Ndungo,Rohini G. Sandesara,Jan E. Carette,Ana I. Kuehne,Gordon Ruthel,Suzanne R. Pfeffer,John M. Dye,Sean P. J. Whelan,Thijn R. Brummelkamp,Kartik Chandran +15 more
TL;DR: These findings support a model in which GP cleavage by endosomal cysteine proteases unmasks the binding site for NPC1, and GP–NPC1 engagement within lysosomes promotes a late step in entry proximal to viral escape into the host cytoplasm.
Journal ArticleDOI
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.
Lucas T. Jae,Matthijs Raaben,Moniek Riemersma,Ellen van Beusekom,Vincent A. Blomen,Arno Velds,Ron M. Kerkhoven,Jan E. Carette,Haluk Topaloglu,Peter Meinecke,Marja W. Wessels,Dirk Lefeber,Sean P. J. Whelan,Hans van Bokhoven,Thijn R. Brummelkamp,Thijn R. Brummelkamp +15 more
TL;DR: Comprehensive forward genetic screens can be used to define the genetic architecture of a complex disease and point out genes defective in dystroglycanopathies.
Journal ArticleDOI
Lassa virus entry requires a trigger-induced receptor switch
Lucas T. Jae,Matthijs Raaben,Andrew S. Herbert,Ana I. Kuehne,Ariel S. Wirchnianski,Timothy K. Soh,Sarah H. Stubbs,Hans Janssen,Markus Damme,Paul Saftig,Sean P. J. Whelan,John M. Dye,Thijn R. Brummelkamp,Thijn R. Brummelkamp +13 more
TL;DR: It is shown that to enter a cell, the virus requires a second receptor, this one inside the infected cell, which sheds light on the “enigmatic resistance” of bird cells to Lassa virus, and the resistance of Lamp1-deficient mice to Lasso virus highlights the relevance of this receptor switch in vivo.
Journal ArticleDOI
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation
Monique H. Verheije,Matthijs Raaben,Muriel Mari,Eddie G. te Lintelo,Fulvio Reggiori,Frank J. M. van Kuppeveld,Peter J. M. Rottier,Cornelis A. M. de Haan +7 more
TL;DR: The results demonstrate that GBF1-mediated ARF1 activation is required for efficient MHV RNA replication and reveal that the early secretory pathway and MHV replication complex formation are closely connected.