M
Mauro Biffoni
Researcher at Istituto Superiore di Sanità
Publications - 98
Citations - 10752
Mauro Biffoni is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Stem cell & Cancer stem cell. The author has an hindex of 34, co-authored 88 publications receiving 9812 citations. Previous affiliations of Mauro Biffoni include Sapienza University of Rome.
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Journal ArticleDOI
Identification and expansion of human colon-cancer-initiating cells
Lucia Ricci-Vitiani,Dario Giuseppe Lombardi,Emanuela Pilozzi,Mauro Biffoni,Matilde Todaro,Cesare Peschle,Ruggero De Maria +6 more
TL;DR: It is concluded that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies.
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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Lucia Ricci-Vitiani,Roberto Pallini,Mauro Biffoni,Matilde Todaro,Gloria Invernici,Tonia Cenci,Giulio Maira,Eugenio Parati,Giorgio Stassi,Luigi Maria Larocca,Ruggero De Maria +10 more
TL;DR: A variable number (range 20–90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin.
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The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities.
Désirée Bonci,Valeria Coppola,Maria Letizia Musumeci,Antonio Addario,Raffaella Giuffrida,Lorenzo Memeo,Leonardo D'Urso,Alfredo Pagliuca,Mauro Biffoni,Catherine Labbaye,Monica Bartucci,Giovanni Muto,Cesare Peschle,Ruggero De Maria +13 more
TL;DR: It is proposed thatmiR-15a and miR-16 act as tumor suppressor genes in prostate cancer through the control of cell survival, proliferation and invasion through the regulation of BCL2 and CCND1.
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CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis
Matilde Todaro,Miriam Gaggianesi,Veronica Catalano,Antonina Benfante,Flora Iovino,Mauro Biffoni,Tiziana Apuzzo,Isabella Sperduti,Silvia Volpe,Gianfranco Cocorullo,Gaspare Gulotta,Francesco Dieli,Ruggero De Maria,Giorgio Stassi +13 more
TL;DR: It is shown that all colorectal cancer stem cells (CR-CSCs) express CD44v6, which is required for their migration and generation of metastatic tumors, and phosphatidylinositol 3-kinase (PI3K) inhibition selectively killed CD 44v6 CR-C SCs and reduced metastatic growth.
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The Promyelocytic Leukemia Zinc Finger–MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms
Federica Felicetti,M. Cristina Errico,Lisabianca Bottero,Patrizia Segnalini,Antonella Stoppacciaro,Mauro Biffoni,Nadia Felli,Gianfranco Mattia,Marina Petrini,Mario P. Colombo,Cesare Peschle,Alessandra Carè +11 more
TL;DR: In vitro and in vivo functional studies, including the use of antisense "antagomir" oligonucleotides, confirmed the key role of miR-221/-222 in regulating the progression of human melanoma; this suggests that targeted therapies suppressing miR -221/222 may prove beneficial in advanced melanoma.