M
Megumu Takahashi
Researcher at Kyoto University
Publications - 23
Citations - 448
Megumu Takahashi is an academic researcher from Kyoto University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 5, co-authored 11 publications receiving 249 citations. Previous affiliations of Megumu Takahashi include Juntendo University.
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Journal ArticleDOI
Single-cell bioluminescence imaging of deep tissue in freely moving animals
Satoshi Iwano,Mayu Sugiyama,Hiroshi Hama,Akiya Watakabe,Naomi Hasegawa,Takahiro Kuchimaru,Kazumasa Z. Tanaka,Megumu Takahashi,Yoko Ishida,Jun-ichi Hata,Satoshi Shimozono,Kana Namiki,Takashi Fukano,Masahiro Kiyama,Hideyuki Okano,Shinae Kizaka-Kondoh,Thomas J. McHugh,Tetsuo Yamamori,Hiroyuki Hioki,Shojiro Maki,Atsushi Miyawaki +20 more
TL;DR: AkaBLI produced emissions in vivo that were brighter by a factor of 100 to 1000 than conventional systems, allowing noninvasive visualization of single cells deep inside freely moving animals, and is therefore a bioengineered light source to spur unprecedented scientific, medical, and industrial applications.
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Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration
Hiroyuki Katayama,Hiroshi Hama,Koji Nagasawa,Hiroshi Kurokawa,Mayu Sugiyama,Ryoko Ando,Masaaki Funata,Nobuyo Yoshida,Misaki Homma,Takanori Nishimura,Megumu Takahashi,Yoko Ishida,Hiroyuki Hioki,Yoshiyuki Tsujihata,Atsushi Miyawaki +14 more
TL;DR: In a mouse model of Parkinsons disease, it is found that dopaminergic neurons selectively failed to execute mitophagy that promoted their survival within lesions, showing that mito-SRAI is an essential tool for quantitative studies of mitochondrial quality control.
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A Single Vector Platform for High-Level Gene Transduction of Central Neurons: Adeno-Associated Virus Vector Equipped with the Tet-Off System.
TL;DR: The AAV-SynTetOff vector developed in the present study exhibits strong fluorescence labeling and has promising applications in neuronal imaging.
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Preferential inputs from cholecystokinin-positive neurons to the somatic compartment of parvalbumin-expressing neurons in the mouse primary somatosensory cortex.
Hiroyuki Hioki,Hiroyuki Hioki,Jaerin Sohn,Hisashi Nakamura,Shinichiro Okamoto,Jungwon Hwang,Yoko Ishida,Megumu Takahashi,Hiroshi Kameda +8 more
TL;DR: The present findings suggest that, by preferentially innervating the cell bodies of PV+ neurons, both CCK+/VIP- basket and CCK/ VIP+ double bouquet cells might efficiently interfere with action potential generation of PV- neurons, and that the two types of CCK- neurons might have a large impact on cortical activity through PV+ neuron inhibition.
Journal ArticleDOI
Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment.
Shinichiro Okamoto,Shinichiro Okamoto,Jaerin Sohn,Takuma Tanaka,Megumu Takahashi,Megumu Takahashi,Yoko Ishida,Kenta Yamauchi,Masato Koike,Fumino Fujiyama,Hiroyuki Hioki +10 more
TL;DR: Direct pathway medium-sized spiny neurons (iMSNs) in the neostriatum are well known to project to the external segment of the globus pallidus (GPe), but it remains unclear how dMSNs and iMSNs converge within the GPe.