M
Mei Harada
Researcher at University of Tokyo
Publications - 9
Citations - 65
Mei Harada is an academic researcher from University of Tokyo. The author has contributed to research in topics: Chirality (chemistry) & Rotaxane. The author has an hindex of 3, co-authored 7 publications receiving 15 citations.
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Journal ArticleDOI
Biosynthesis of Indole Diterpene Lolitrems: Radical‐Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton
Yulu Jiang,Taro Ozaki,Mei Harada,Tadachika Miyasaka,Hajime Sato,Kazunori Miyamoto,Junichiro Kanazawa,Chengwei Liu,Chengwei Liu,Jun-ichi Maruyama,Masaatsu Adachi,Atsuo Nakazaki,Toshio Nishikawa,Masanobu Uchiyama,Atsushi Minami,Hideaki Oikawa +15 more
TL;DR: This work reconstitute the biosynthetic pathway for lolitrems employing a recently established genome-editing technique for the expression host Aspergillus oryzae and isolated the key reaction intermediate with an epoxyalcohol moiety.
Journal ArticleDOI
Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins.
Shotaro Shimo,Richiro Ushimaru,Alicia Engelbrecht,Mei Harada,Kazunori Miyamoto,Andreas Kulik,Masanobu Uchiyama,Masanobu Uchiyama,Leonard Kaysser,Ikuro Abe +9 more
TL;DR: In this paper, it was shown that cyclopropanases can remove the 4-proS-H of 6-nitronorleucine during the cyclization, establishing the inversion and retention of the configuration at C4 during the BelL and HrmJ reactions.
Journal ArticleDOI
Cubane Chirality via Substitution of a "Hidden" Regular Tetrahedron.
Nana Yoshino,Yumi Kato,Thibaud Mabit,Yuuya Nagata,Craig M. Williams,Mei Harada,Atsuya Muranaka,Masanobu Uchiyama,Seijiro Matsubara +8 more
TL;DR: 1,3-dibromo-4-deuteriocubane-N,N-diisopropylcarboxamide is prepared, which upon treatment with zincates affords 1,3,5-trisubstituted cubanes via simultaneous two-position substitution reactions.
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α‐Cyclodextrin Encapsulation of Bicyclo[1.1.1]pentane Derivatives: A Storable Feedstock for Preparation of [1.1.1]Propellane
Tadafumi Matsunaga,Junichiro Kanazawa,Tomohiro Ichikawa,Mei Harada,Yusuke Nishiyama,Nghia Tuan Duong,Takashi Matsumoto,Kazunori Miyamoto,Masanobu Uchiyama +8 more
TL;DR: The α-cyclodextrin (α-CD) encapsulation of BCP derivatives is reported, affording a stable, readily storable material from which BCPs can be easily and quantitatively recovered.
Journal ArticleDOI
A remarkably air-stable quinodimethane radical cation.
Mei Harada,Masaru Tanioka,Masaru Tanioka,Atsuya Muranaka,Tetsuya Aoyama,Shinichiro Kamino,Masanobu Uchiyama,Masanobu Uchiyama +7 more
TL;DR: An ambient-stable radical cation of a Thiele's hydrocarbon derivative has been synthesized and its properties have been explored using a combined experimental and computational approach.