Meltem Gürel

TL;DR: These findings support an adaptive shift toward AR-V-mediated signaling in a subset of CRPC tumors as the AR-LBD is rendered inactive, suggesting an important mechanism contributing to drug resistance to CRPC therapy.

TL;DR: This case illustrates the potential need in precision medicine to longitudinally sample metastatic lesions to capture the evolving constellation of alterations during progression and highlights the potential importance of developing and implementing molecular prognostic and predictive markers to augment current pathological evaluation and delineate clonal heterogeneity.

TL;DR: It is shown that somatic DNA methylation alterations, despite showing marked interindividual heterogeneity among men with lethal metastatic prostate cancer, were maintained across all metastases within the same individual, and the overall extent of maintenance in DNAmethylation changes was comparable to that of genetic copy number alterations.

TL;DR: It is reported that this is the first description of human IL-6R deficiency in two patients presenting with recurrent infections, atopy, elevated IgE, and abnormal acute-phase responses.

TL;DR: Governing-wide transcriptome analysis of highly refined CML and normal stem and progenitor cell populations was performed to identify novel targets for the eradication of CML LSCs using exon microarrays, identifying 97 genes that were differentially expressed in CML versus normalstem and progensitor cells.