R
Ravishankar Sargur
Researcher at University of Sheffield
Publications - 40
Citations - 1359
Ravishankar Sargur is an academic researcher from University of Sheffield. The author has contributed to research in topics: Primary immunodeficiency & Penetrance. The author has an hindex of 17, co-authored 34 publications receiving 952 citations. Previous affiliations of Ravishankar Sargur include National Health Service & Northern General Hospital.
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Journal ArticleDOI
Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans
Paul Tuijnenburg,Hana Lango Allen,Hana Lango Allen,Siobhan O. Burns,Daniel Greene,Daniel Greene,Machiel H. Jansen,Emily Staples,Jonathan Stephens,Jonathan Stephens,Keren J. Carss,Keren J. Carss,Daniele Biasci,Helen Baxendale,Moira Thomas,Anita Chandra,Sorena Kiani-Alikhan,Hilary Longhurst,Suranjith L. Seneviratne,Eric Oksenhendler,Ilenia Simeoni,Godelieve J. de Bree,Anton T.J. Tool,Ester M. M. van Leeuwen,Eduard H T M Ebberink,Alexander B. Meijer,Salih Tuna,Salih Tuna,Deborah Whitehorn,Deborah Whitehorn,Matthew A. Brown,Matthew A. Brown,Ernest Turro,Ernest Turro,Adrian J. Thrasher,Kenneth G. C. Smith,James Ed Thaventhiran,Taco W. Kuijpers,Zoe Adhya,Hana Alachkar,Ariharan Anantharachagan,Richard Antrobus,Gururaj Arumugakani,Chiara Bacchelli,Claire Bethune,Shahnaz Bibi,Barbara Boardman,Claire Booth,Michael J. Browning,Mary Brownlie,Siobhan Burns,Hayley Clifford,Nichola Cooper,Sophie Davies,John Dempster,Lisa Devlin,Rainer Doffinger,Elizabeth Drewe,David Edgar,William Egner,Tariq El-Shanawany,Bobby Gaspar,Rohit Ghurye,Kimberley Gilmour,Sarah Goddard,Pavel Gordins,Sofia Grigoriadou,Scott Hackett,Rosie Hague,Lorraine Harper,Grant Hayman,A Herwadkar,Stephen M. Hughes,Aarnoud Huissoon,Stephen Jolles,Julie Jones,Peter Kelleher,Nigel Klein,Taco W. Kuijpers,Dinakantha S. Kumararatne,James Laffan,Sara Lear,Hilary Longhurst,Lorena Lorenzo,Jesmeen Maimaris,Ania Manson,Elizabeth M. McDermott,Hazel Millar,Anoop Mistry,Valerie Morrisson,Sai Murng,Iman Nasir,Sergey Nejentsev,Sadia Noorani,Mark J. Ponsford,Waseem Qasim,Ellen Quinn,Isabella Quinti,Alex G. Richter,Crina Samarghitean,Ravishankar Sargur,Sinisa Savic,Suranjith L. Seneviratne,Carrock Sewall,Fiona Shackley,Hans J. Stauss,Cathal Laurence Steele,James Thaventhiran,Adrian J. Thrasher,Steve Welch,Lisa C. Willcocks,Sarita Workman,Austen Worth,Nigel Yeatman,Patrick F.K. Yong,Sofie Ashford,John Bradley,Debra Fletcher,Tracey Hammerton,Roger James,Nathalie Kingston,Willem H. Ouwehand,Christopher J. Penkett,F. Lucy Raymond,Kathleen Stirrups,Marijke Veltman,Tim Young,Naomi Clements-Brod,John Davis,Eleanor Dewhurst,Marie Erwood,Amy Frary,Rachel Linger,Jennifer M. Martin,Sofia Papadia,Karola Rehnstrom,William J. Astle,Antony P. Attwood,Marta Bleda,Keren J. Carss,Louise C. Daugherty,Sri V V Deevi,Stefan Gräf,Csaba Halmagyi,Matthias Haimel,Fengyuan Hu,Vera Matser,Stuart Meacham,Karyn Megy,Olga Shamardina,Catherine Titterton,Ping Yu,Julie von Ziegenweldt,Abigail Furnell,Rutendo Mapeta,Simon Staines,Paula Rayner-Matthews,Christopher Watt +157 more
TL;DR: It is shown that heterozygous loss‐of‐function variants in NFKB1 are the most common known monogenic cause of CVID, which results in a temporally progressive defect in the formation of immunoglobulin‐producing B cells.
Journal ArticleDOI
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
Sarah Spencer,Sevgi Köstel Bal,William Egner,William Egner,Hana Lango Allen,Hana Lango Allen,Syed Irfan Raza,Chi Ma,Meltem Gürel,Yuan Zhang,Guangping Sun,Ruth A. Sabroe,Daniel Greene,Daniel Greene,William Rae,Tala Shahin,Katarzyna D. Kania,Rico Chandra Ardy,Marini Thian,Emily Staples,Annika Pecchia-Bekkum,William P.M. Worrall,Jonathan Stephens,Jonathan Stephens,Matthew A. Brown,Matthew A. Brown,Salih Tuna,Salih Tuna,Melanie York,Melanie York,Fiona Shackley,Fiona Shackley,Diarmuid Kerrin,Ravishankar Sargur,Ravishankar Sargur,Alison M. Condliffe,Alison M. Condliffe,Hamid Nawaz Tipu,Hye Sun Kuehn,Sergio D. Rosenzweig,Ernest Turro,Simon Tavaré,Simon Tavaré,Adrian J. Thrasher,Duncan I. Jodrell,Kenneth G. C. Smith,Kaan Boztug,Joshua D. Milner,James Thaventhiran +48 more
TL;DR: It is reported that this is the first description of human IL-6R deficiency in two patients presenting with recurrent infections, atopy, elevated IgE, and abnormal acute-phase responses.
Journal ArticleDOI
British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders
John R. Hurst,Nisha Verma,David M. Lowe,Helen Baxendale,Stephen Jolles,Peter Kelleher,Hilary Longhurst,Smita Y. Patel,Elisabetta A. Renzoni,Clare R. Sander,Gerard R. Avery,Judith Babar,Matthew Buckland,Siobhan O. Burns,William Egner,Mark Gompels,Pavels Gordins,Jamanda Haddock,Simon P. Hart,Grant Hayman,Richard Herriot,Rachel K. Hoyles,Aarnoud Huissoon,Joseph Jacob,Andrew G. Nicholson,Doris M Rassl,Ravishankar Sargur,Sinisa Savic,Suranjith L. Seneviratne,Michael Sheaff,Prashantha M. Vaitla,Gareth I. Walters,Joanna L. Whitehouse,Penny Wright,Alison M. Condliffe +34 more
TL;DR: A proportion of people living with common variable immunodeficiency disorders develop granulomatous-lymphocytic interstitial lung disease (GLILD), and a consensus statement on the definition, diagnosis, and management of GLILD was developed.
Journal ArticleDOI
The United Kingdom Primary Immune Deficiency (UKPID) Registry: report of the first 4 years' activity 2008-2012
JD Edgar,Matthew Buckland,David Guzman,Niall Conlon,Viviane Knerr,C. Bangs,Veronika Reiser,Z. Panahloo,Sarita Workman,Mary Slatter,Andrew R. Gennery,EG Davies,Z. Allwood,Peter D. Arkwright,Matthew Helbert,Hilary Longhurst,Sofia Grigoriadou,Lisa Devlin,Aarnoud Huissoon,M T Krishna,Scott Hackett,Dinakantha S. Kumararatne,Alison M. Condliffe,Helen Baxendale,Katherine Henderson,Claire Bethune,Christine Symons,P. Wood,K. Ford,Smita Y. Patel,Rashmi Jain,Stephen Jolles,Tariq El-Shanawany,H. Alachkar,A Herwadkar,Ravishankar Sargur,Anna Shrimpton,Grant Hayman,M. Abuzakouk,Gavin P. Spickett,C. J. Darroch,Stéphane Paulus,S. E. Marshall,E. McDermott,Paul T. Heath,Richard Herriot,Sadia Noorani,Marc Turner,Sujoy Khan,Bodo Grimbacher +49 more
TL;DR: Data is presented on the range of diagnoses recorded, estimated minimum disease prevalence, geographical distribution of patients across the United Kingdom, age at presentation, diagnostic delay, treatment modalities used and evidence of their monitoring and effectiveness.
Journal ArticleDOI
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
Thaventhiran Jed.,Hana Lango Allen,Oliver S. Burren,William Rae,Daniel Greene,Emily Staples,Zinan Zhang,Zinan Zhang,Farmery Jhr.,Ilenia Simeoni,Elizabeth Rivers,Elizabeth Rivers,Jesmeen Maimaris,Jesmeen Maimaris,Christopher J. Penkett,Jonathan Stephens,Jonathan Stephens,Deevi Svv.,Alba Sanchis-Juan,Alba Sanchis-Juan,Nicholas Gleadall,Nicholas Gleadall,Moira Thomas,Moira Thomas,Ravishankar Sargur,Pavels Gordins,Helen Baxendale,Helen Baxendale,Matthew A. Brown,Paul Tuijnenburg,Paul Tuijnenburg,Austen Worth,Austen Worth,Steven Hanson,Steven Hanson,Rachel Linger,Matthew Buckland,Matthew Buckland,Paula Rayner-Matthews,Kimberly Gilmour,Kimberly Gilmour,Crina Samarghitean,Suranjith L. Seneviratne,Suranjith L. Seneviratne,David M. Sansom,David M. Sansom,Andy G. Lynch,Andy G. Lynch,Karyn Megy,Eva Ellinghaus,David Ellinghaus,David Ellinghaus,Silje F. Jørgensen,Tom H. Karlsen,Kathleen Stirrups,Antony J. Cutler,Dinakantha S. Kumararatne,Anita Chandra,Edgar Jdm.,A Herwadkar,Nichola Cooper,S Grigoriadou,Aarnoud Huissoon,Sarah Goddard,Stephen Jolles,Catharina Schuetz,F Boschann,Paul A. Lyons,Matthew E. Hurles,Sinisa Savic,Siobhan O. Burns,Siobhan O. Burns,Taco W. Kuijpers,Taco W. Kuijpers,Ernest Turro,Willem H. Ouwehand,Adrian J. Thrasher,Adrian J. Thrasher,Smith Kgc. +78 more
TL;DR: Whole-genome sequencing analysis of individuals with primary immunodeficiency identifies new candidate disease-associated genes and shows how the interplay between genetic variants can explain the variable penetrance and complexity of the disease.