Meredith Spindler

TL;DR: This study provides Class III evidence that for patients with PD, virtual house calls from a neurologist are feasible and do not significantly change quality of life compared to in-person visits.

TL;DR: The past, present, and likely future applications of telemedicine to PD are described, including integrated care networks that connect patients to a wide range of providers; education programs that support patients and health care providers; and new research applications that include remote monitoring and remote visits.

TL;DR: F-AV-1451 is a PET radioligand that achieves in vivo binding in Alzheimer’s disease (AD) and autoradiographic evidence of binding to paired helical filaments (PHFs) composed of 3-repeat misfolded tau and 4Rtau characteristic of AD histopathology is reported.

TL;DR: While nilotinib demonstrated acceptable safety and tolerability in this cohort, the low cerebrospinal fluid exposure, lack of biomarkers effects, and efficacy data trending in the negative direction indicate that further testing ofnilotinib in treatment of Parkinson disease is not warranted.

TL;DR: Higher antemortem CSF t-tau/Aβ1-42 and lower Aβ1/42 levels are predictive of increasing cerebral AD and SYN pathology, which may identify patients with LBD vulnerable to cortical SYn pathology who may benefit from both SYN and AD-targeted disease-modifying therapies.