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Merja Heinäniemi
Researcher at University of Eastern Finland
Publications - 84
Citations - 2175
Merja Heinäniemi is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 24, co-authored 62 publications receiving 1596 citations. Previous affiliations of Merja Heinäniemi include University at Buffalo & University of Luxembourg.
Papers
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Journal ArticleDOI
DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3
Natalia Pendás-Franco,Jose M. Garcia,Cristina Peña,Noelia Valle,Hector G. Palmer,Merja Heinäniemi,Carsten Carlberg,Benilde Jiménez,Benilde Jiménez,Félix Bonilla,Alberto Muñoz,José Manuel González-Sancho,José Manuel González-Sancho +12 more
TL;DR: DKK-4 is upregulated in colon cancer and is associated with the acquisition of malignant properties by neoplastic cells and downregulation is a novel effect of 1,25(OH)2D3 that may contribute to its anticancer action.
Book ChapterDOI
Role of the Keap1-Nrf2 pathway in cancer.
TL;DR: The current understanding of the regulation of Nrf2 in normal cells as well as its dual role in cancer are reviewed.
Journal ArticleDOI
Gene-pair expression signatures reveal lineage control
Merja Heinäniemi,Matti Nykter,Matti Nykter,Roger Kramer,Anke Wienecke-Baldacchino,Lasse Sinkkonen,Joseph X. Zhou,Joseph X. Zhou,Richard Kreisberg,Stuart A. Kauffman,Sui Huang,Sui Huang,Ilya Shmulevich +12 more
TL;DR: This work curated human expression data and developed a data-driven method for identifying putative determinants of cell fate built around the concept of expression reversal of gene pairs, such as those participating in toggle-switch circuits.
Journal ArticleDOI
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease
Abhimanyu Krishna,Maria Biryukov,Christophe Trefois,Paul Antony,Rene Hussong,Jake Lin,Merja Heinäniemi,Gustavo Glusman,Sandra Köglsberger,Olga Boyd,Bart H. J. van den Berg,Dennis Linke,David Huang,Kai Wang,Leroy Hood,Andreas Tholey,Reinhard Schneider,David J. Galas,Rudi Balling,Patrick May,Patrick May +20 more
TL;DR: The systems genomics approach showed consistency across different biological levels (DNA, RNA and protein concentrations).
Journal ArticleDOI
Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis
David L. M. van der Meer,Tatjana Degenhardt,Sami Väisänen,Philip J. de Groot,Merja Heinäniemi,Sacco C. de Vries,Michael Müller,Carsten Carlberg,Sander Kersten +8 more
TL;DR: ChIP-chip analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARα in human liver and highlight the importance of cross-talk with other transcription factors.