M
Merribeth J. Morin
Researcher at PATH
Publications - 20
Citations - 702
Merribeth J. Morin is an academic researcher from PATH. The author has contributed to research in topics: Plasmodium falciparum & Circumsporozoite protein. The author has an hindex of 10, co-authored 20 publications receiving 540 citations.
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Journal ArticleDOI
Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers.
Teun Bousema,Teun Bousema,Rhoel R. Dinglasan,Isabelle Morlais,Louis Clément Gouagna,Travis van Warmerdam,Parfait Awono-Ambene,Sarah Bonnet,Mouctar Diallo,Mamadou B. Coulibaly,Timoléon Tchuinkam,Timoléon Tchuinkam,Bert Mulder,G. A. T. Targett,Chris Drakeley,Colin J. Sutherland,Vincent Robert,Ogobara K. Doumbo,Yeya T. Touré,Patricia M. Graves,Will Roeffen,Robert W. Sauerwein,Ashley J. Birkett,Emily Locke,Merribeth J. Morin,Yimin Wu,Thomas S. Churcher +26 more
TL;DR: Despite a higher efficiency of direct skin feeding assay procedures, membrane feeding assays appear suitable tools to compare the infectiousness between individuals and to evaluate transmission-reducing interventions.
Journal ArticleDOI
Qualification of standard membrane-feeding assay with Plasmodium falciparum malaria and potential improvements for future assays.
Kazutoyo Miura,Bingbing Deng,Gregory Tullo,Ababacar Diouf,Samuel E. Moretz,Emily Locke,Merribeth J. Morin,Michael P. Fay,Carole A. Long +8 more
TL;DR: The standard membrane-feeding assay (SMFA) is one of the few biological assays used in preclinical and early clinical development of transmission-blocking vaccines, and this study strongly supports its further development and application.
Journal ArticleDOI
Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults
Jessica A. Chichester,Brian J. Green,R. Mark Jones,Yoko Shoji,Kazutoyo Miura,Carole A. Long,Cynthia K. Lee,Christian F. Ockenhouse,Merribeth J. Morin,Stephen J. Streatfield,Vidadi Yusibov +10 more
TL;DR: The vaccine candidate displays an acceptable safety and tolerability profile and induced Pfs25-specific IgG in a dose dependent manner but low transmission reducing activity implies need for an improved formulation.
Journal ArticleDOI
Development of a transmission-blocking malaria vaccine: progress, challenges, and the path forward.
Julia K. Nunes,Colleen C. Woods,Terrell Carter,Theresa Raphael,Merribeth J. Morin,Diadier Diallo,Didier Leboulleux,Sanjay Jain,Christian Loucq,David C. Kaslow,Ashley J. Birkett +10 more
TL;DR: The progress made in critical areas since 2010 is described, key challenges that remain are highlighted, and important next steps to maximize the potential for SSM-VIMTs to contribute to the broader malaria elimination and eradication objectives are outlined.
Journal ArticleDOI
Structural delineation of potent transmission-blocking epitope I on malaria antigen Pfs48/45.
P. Kundu,A. Semesi,Matthijs M. Jore,Merribeth J. Morin,V.L. Price,A. Liang,J. Li,Kazutoyo Miura,Robert W. Sauerwein,C.R. King,Jean-Philippe Julien +10 more
TL;DR: This work reveals how the Pfs48/45 6C domain adopts a (SAG1)-related-sequence (SRS) fold and structurally delineates potent epitope I and shows how mAb 85RF45.1 recognizes an electronegative surface with nanomolar affinity.