M
Mi Shi
Researcher at University of Pennsylvania
Publications - 23
Citations - 1110
Mi Shi is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 15, co-authored 23 publications receiving 964 citations. Previous affiliations of Mi Shi include Howard Hughes Medical Institute & Dartmouth College.
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Book ChapterDOI
Enabling a community to dissect an organism: overview of the Neurospora functional genomics project.
Jay C. Dunlap,Katherine A. Borkovich,Matthew R. Henn,Gloria E. Turner,Matthew S. Sachs,N. Louise Glass,Kevin McCluskey,Michael Plamann,James E. Galagan,Bruce W. Birren,Richard L. Weiss,Jeffrey P. Townsend,Jennifer J. Loros,Mary Anne Nelson,Randy Lambreghts,Hildur V. Colot,Gyungsoon Park,Patrick D. Collopy,Carol S. Ringelberg,Christopher M. Crew,Liubov Litvinkova,David DeCaprio,Heather M. Hood,Susan Curilla,Mi Shi,Matthew Crawford,Michael Koerhsen,Phil Montgomery,Lisa Larson,Matthew D. Pearson,Takao Kasuga,Chaoguang Tian,Meray Baştürkmen,Lorena Altamirano,Junhuan Xu +34 more
TL;DR: CDNA libraries generated in Project 4 document the overall complexity of expressed sequences in Neurospora, including alternative splicing alternative promoters and antisense transcripts, and drive the assembly of an SNP map presently populated by nearly 300 markers that will greatly accelerate the positional cloning of genes.
Journal ArticleDOI
The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output
William J. Belden,Luis F. Larrondo,Allan C. Froehlich,Mi Shi,Chen-Hui Chen,Jennifer J. Loros,Jay C. Dunlap +6 more
TL;DR: The data suggest that interconnected RAS- and ROS-responsive signaling pathways regulate the amplitude of circadian- and light-regulated gene expression in Neurospora.
Journal ArticleDOI
A Role for Casein Kinase 2 in the Mechanism Underlying Circadian Temperature Compensation
TL;DR: Casein kinase 2 (CK2) is identified as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, displaying distinctive alterations in compensation encode the beta1 and alpha subunits of CK2, respectively.
Journal ArticleDOI
Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount
TL;DR: It is proposed that the homeostatic drive to sleep increases levels of RYE, which responds to this drive by promoting sleep.
Journal ArticleDOI
A circadian clock in Neurospora: how genes and proteins cooperate to produce a sustained, entrainable, and compensated biological oscillator with a period of about a day.
Jay C. Dunlap,Jennifer J. Loros,Hildur V. Colot,Arun Mehra,William J. Belden,Mi Shi,Christian I. Hong,Luis F. Larrondo,Christopher L. Baker,Chen-Hui Chen,Carsten Schwerdtfeger,Patrick D. Collopy,Joshua J. Gamsby,Randy Lambreghts +13 more
TL;DR: The data promise molecular explanations for all of the canonical circadian properties of this model system, providing biochemical answers and regulatory logic that may be extended to more complex eukaryotes including humans.