M
Michael D. Varney
Researcher at Australian Red Cross Blood Service
Publications - 39
Citations - 1808
Michael D. Varney is an academic researcher from Australian Red Cross Blood Service. The author has contributed to research in topics: Human leukocyte antigen & Genotyping. The author has an hindex of 21, co-authored 39 publications receiving 1715 citations. Previous affiliations of Michael D. Varney include Columbia University & Royal Melbourne Hospital.
Papers
More filters
Journal ArticleDOI
The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes.
Spiros Fourlanos,Michael D. Varney,Brian D. Tait,Grant Morahan,Margo C. Honeyman,Peter G. Colman,Leonard C. Harrison +6 more
TL;DR: The rising incidence and decreasing age at diagnosis of type 1 diabetes is accounted for by the impact of environment on children with lower-risk HLA class II genes, who previously would not have developed type 1abetes in childhood.
Journal ArticleDOI
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium.
Janelle A. Noble,Ana M. Valdes,Michael D. Varney,Joyce Carlson,P. V. Moonsamy,Anna Lisa Fear,Julie A. Lane,Eva Lavant,Rebecca Rappner,Anthony Louey,Patrick Concannon,Josyf C. Mychaleckyj,Henry A. Erlich +12 more
TL;DR: Genotyping data and type 1 diabetes association analyses for HLA class I loci on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study, indicate that Hla class I alleles, in addition to and independently from HLAclass II alleles are associated with type 1 Diabetes.
Journal ArticleDOI
Common and well-documented HLA alleles: 2012 update to the CWD catalogue.
Steven J. Mack,Pedro Cano,Jill A. Hollenbach,Jun He,Carolyn Katovich Hurley,Derek Middleton,M. E. Moraes,Shalini E. Pereira,Jane Kempenich,Elaine F. Reed,Michelle Setterholm,Anajane G. Smith,Marcel G.J. Tilanus,Margareth Torres,Michael D. Varney,Christien Voorter,Gottfried Fischer,Katharina Fleischhauer,Damian Goodridge,William Klitz,AM Little,Martin Maiers,Steven G.E. Marsh,Carlheinz Müller,Harriet Noreen,Erik H. Rozemuller,Alicia Sanchez-Mazas,David Senitzer,Elizabeth Trachtenberg,Marcelo Fernandez-Vina +29 more
TL;DR: The CWD catalogue will be updated on a regular basis moving forward, and will incorporate changes to the IMGT/HLA Database as well as empirical data from the histocompatibility and immunogenetics community.
Journal ArticleDOI
Approach to the total synthesis of chlorothricolide: synthesis of (.+-.)-19,20-dihydro-24-O-methylchlorothricolide methyl ester ethyl carbonate
TL;DR: In this paper, an approach to the total synthesis of the 14-membered macrolide antibiotic aglycon chlorothricolide is presented, which includes initial esterification across the C1 and C25 carbons followed by macrodilactonization across C17 and C14 carbons.
Journal ArticleDOI
Definition of High-Risk Type 1 Diabetes HLA-DR and HLA-DQ Types Using Only Three Single Nucleotide Polymorphisms
TL;DR: A novel machine learning method is developed that predicts HLA-DR/DQ types relevant to T1D more accurately than existing methods and is rapid and cost-effective.