M
Michael G. Rosenfeld
Researcher at University of California, San Diego
Publications - 522
Citations - 112098
Michael G. Rosenfeld is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 178, co-authored 504 publications receiving 107707 citations. Previous affiliations of Michael G. Rosenfeld include Tokai University & Salk Institute for Biological Studies.
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Journal ArticleDOI
Molecular determinants of resistance to antiandrogen therapy
Charlie D. Chen,Derek S. Welsbie,Chris Tran,Sung Hee Baek,Randy Chen,Robert L. Vessella,Michael G. Rosenfeld,Charles L. Sawyers +7 more
TL;DR: Using microarray-based profiling of isogenic prostate cancer xenograft models, it is found that a modest increase in androgen receptor mRNA was the only change consistently associated with the development of resistance to antiandrogen therapy.
Journal ArticleDOI
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
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The coregulator exchange in transcriptional functions of nuclear receptors
TL;DR: Based on their importance in biology and medicine, as well as the relatively simple mechanism of regulation, NR represent one of the most intensively studied and best-understood classes of transcription factors at the molecular level.
Journal ArticleDOI
A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors
Yasutomi Kamei,Lan Xu,Thorsten Heinzel,Joseph Torchia,Riki Kurokawa,Bernd Gloss,Sheng-Cai Lin,Richard A. Heyman,David W. Rose,Christopher K. Glass,Michael G. Rosenfeld +10 more
TL;DR: It is suggested that CBP/p300 serves as an integrator of multiple signal transduction pathways within the nucleus, in addition to distinct coactivators for function of nuclear receptors, CREB, and AP-1.
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Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
Andreas J. Horlein,Anders M. Näär,Thorsten Heinzel,Joseph Torchia,Bernd Gloss,Riki Kurokawa,Aimee K. Ryan,Yasutomi Kamei,Mats Söderström,Christopher K. Glass,Michael G. Rosenfeld +10 more
TL;DR: A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co- repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.